N-acylbenzotriazoles:: Neutral acylating reagents for the preparation of primary, secondary, and tertiary amides
N-acylbenzotriazoles:: Neutral acylating reagents for the preparation of primary, secondary, and tertiary amides
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DOI：
10.1021/jo000792f
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发表时间：
2000-12-01
影响因子：
3.6
通讯作者：
Suzuki, K
中科院分区：
文献类型：
--
作者：
Katritzky, AR;He, HY;Suzuki, K
容易获得的N-酰基苯并三唑2a-q有效地酰化氨水和伯胺和仲胺，以良好至优异的产率得到伯酰胺、仲酰胺和叔酰胺。通过（i）由α-羟基酸制备α-羟基酰胺和（ii）全氟烷基化酰胺来说明该方法的广泛适用性。
Readily available N-acylbenzotriazoles 2a-q efficiently acylate aqueous ammonia and primary and secondary amines to give primary, secondary, and tertiary amides in good to excellent yields. The wide applicability of the procedure is illustrated by the preparation of (i) alpha -hydroxyamides from alpha -hydroxy acids and of(ii) perfluoroalkylated amides.