RNA Polymerase II Elongation at the Crossroads of Transcription and Alternative Splicing.
RNA Polymerase II Elongation at the Crossroads of Transcription and Alternative Splicing.
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RNA聚合酶II伸长在转录和替代剪接的十字路口。
DOI：
10.4061/2011/309865
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发表时间：
2011
影响因子：
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通讯作者：
Kornblihtt AR
中科院分区：
文献类型：
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作者：
de la Mata M;Muñoz MJ;Alló M;Fededa JP;Schor IE;Kornblihtt AR
转录的延伸阶段是导致选择性剪接调节的几个同时和耦合事件的核心。虽然过去被低估，但正是在转录周期的这一阶段，影响转录机制本身、染色质结构、转录后基因调控和前mRNA加工的复合物会聚在一起，相互调控，或者只是巩固更高级的复合物和功能。本文着重于转录延伸过程中发生的多个过程，最终调节选择性剪接决定的结果。
The elongation phase of transcription lies at the core of several simultaneous and coupled events leading to alternative splicing regulation. Although underestimated in the past, it is at this phase of the transcription cycle where complexes affecting the transcription machinery itself, chromatin structure, posttranscriptional gene regulation and pre-mRNA processing converge to regulate each other or simply to consolidate higher-order complexes and functions. This paper focuses on the multiple processes that take place during transcription elongation which ultimately regulate the outcome of alternative splicing decisions.