Methylthioadenosine
Methylthioadenosine
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DOI：
10.1016/j.biocel.2003.11.016
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发表时间：
2004-11-01
影响因子：
4
通讯作者：
Mato, JM
中科院分区：
文献类型：
--
作者：
Avila, MA;García-Trevijano, ER;Mato, JM
5‘-甲硫腺苷(MTA)是一种天然存在的含硫核苷，存在于所有哺乳动物组织中。NITA是由S-腺苷硫氨酸主要通过多胺生物合成途径产生的，在多胺生物合成途径中，它是一种强大的抑制产物。这种化合物只被MTA-磷酸化酶代谢，产生5-甲硫代-1-磷酸和腺嘌呤，这分别是蛋氨酸和嘌呤挽救途径中的关键一步。随着时间的推移，大量证据表明MTA可以在许多方面影响细胞过程。NITA已被证明影响细胞的许多关键反应，包括调节基因表达、增殖、分化和凋亡。虽然大多数这些反应都是在药理学水平上观察到的，但它们的特异性使得人们很容易推测内源性NITA可能在细胞中发挥调节作用。最后，在肝脏损伤和癌症模型中进行的观察表明，NITA的治疗潜力值得进一步考虑。(C)2003爱思唯尔有限公司。保留所有权利。
5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues. NITA is produced from S-adenosylinethionine mainly through the polyamine biosynthetic pathway, where it behaves as a powerful inhibitory product. This compound is metabolized solely by MTA-phosphorylase, to yield 5-methylthioribose-1-phosphate and adenine, a crucial step in the methionine and purine salvage pathways, respectively. Abundant evidence has accumulated over time suggesting that MTA can affect cellular processes in many ways. NITA has been shown to influence numerous critical responses of the cell including regulation of gene expression, proliferation, differentiation and apoptosis. Although most of these responses have been observed at the pharmacological level, their specificity makes it tempting to speculate that endogenous NITA could play a regulatory role in the cell. Finally, observations carried out in models of liver damage and cancer demonstrate a therapeutic potential for NITA that deserves further consideration. (C) 2003 Elsevier Ltd. All rights reserved.