LEFT-VENTRICULAR MASS AND EXERCISE RESPONSES PREDICT FUTURE BLOOD-PRESSURE - THE MUSCATINE STUDY
LEFT-VENTRICULAR MASS AND EXERCISE RESPONSES PREDICT FUTURE BLOOD-PRESSURE - THE MUSCATINE STUDY
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DOI：
10.1161/01.hyp.12.2.206
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发表时间：
1988-08-01
期刊：
影响因子：
8.3
通讯作者：
LAUER, RM
中科院分区：
文献类型：
--
作者：
MAHONEY, LT;SCHIEKEN, RM;LAUER, RM
血压升高和左心室质量增加与成人冠心病发病率和死亡率增加相关。为了确定随后儿童血压和左心室质量的预测因素，对274名6至15岁收缩压处于高、中、低范围的儿童进行了运动期间连续超声心动图和血压反应的研究。在平均3.4年的随访期内，静息和运动时左心室质量和血压的等级顺序持续存在，相关性范围为0.33至0.44。随后的收缩压最好从初始静息和最大运动收缩压和左心室质量预测。随后的左心室质量是最好的预测，从初始左心室质量和最大运动舒张压，但静息收缩压并没有添加到后者的预测。由于左心室质量与运动血压相关性最好，而与静息血压无关，因此左心室质量可以提供静息和应激期间血压影响的综合视图。我们推测，儿童期左心室质量增加可能是继发性高血压及其后果的一个重要预测因素。
Increased blood pressure and left ventricular mass are associated with increased morbidity and mortality in adults with coronary heart disease. To define the predictors of subsequent childhood blood pressure and left ventricular mass, serial echocardiograms and blood pressure responses during exercise were studied in 274 children aged 6 to 15 years, whose systolic blood pressures were in the high, middle, or low range. Persistence of rank order for left ventricular mass and blood pressure, at rest and during exercise, was maintained over a mean follow-up period of 3.4 years, with correlations ranging from 0.33 to 0.44. Subsequent systolic blood pressure was best predicted from initial resting and maximal exercise systolic blood pressures and left ventricular mass. Subsequent left ventricular mass was best predicted from initial left ventricular mass and maximal exercise diastolic blood pressure, but resting systolic blood pressure did not add to this latter prediction. Since left ventricular mass relates best to exercise blood pressure and not to resting blood pressure, left ventricular mass may provide an integrated view of the effects of blood pressure both at rest and during stress. We speculate that increased left ventricular mass in childhood may be an important predictor of subsequent hypertension and its consequences.