Dorsal root ganglion - a potential new therapeutic target for neuropathic pain.
Dorsal root ganglion - a potential new therapeutic target for neuropathic pain.
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DOI：
10.2147/jpr.s26603
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发表时间：
2012
影响因子：
2.7
通讯作者：
Puljak L
中科院分区：
文献类型：
--
作者：
Sapunar D;Kostic S;Banozic A;Puljak L
区域方法可以保护我们的患者免受系统应用药物产生的通常不可接受的不良反应。区域治疗方法，以及在周围神经系统，特别是背根神经节（DRG）的水平上的干预，代表了治疗剂的全身应用的替代方案。本文概述了背根神经节的解剖学特点，解释了为什么背根神经节是一个重要的治疗靶点，以及靶向给药的动物模型如何帮助我们将基础研究转化为临床实践。
A regional approach can protect our patients from often unacceptable adverse effects produced by systematically applied drugs. Regional therapeutic approaches, as well as interventions at the level of the peripheral nervous system and particularly the dorsal root ganglion (DRG), represent an alternative to the systemic application of therapeutic agents. This article provides an overview of DRG anatomical peculiarities, explains why the DRG is an important therapeutic target, and how animal models of targeted drug delivery can help us in the translation of basic research into clinical practice.