HYPOPHYSEAL RESPONSES TO CONTINUOUS AND INTERMITTENT DELIVERY OF HYPOTHALAMIC GONADOTROPIN-RELEASING HORMONE
HYPOPHYSEAL RESPONSES TO CONTINUOUS AND INTERMITTENT DELIVERY OF HYPOTHALAMIC GONADOTROPIN-RELEASING HORMONE
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DOI：
10.1126/science.100883
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发表时间：
1978-01-01
期刊：
影响因子：
56.9
通讯作者：
KNOBIL, E
中科院分区：
文献类型：
--
作者：
BELCHETZ, PE;PLANT, TM;KNOBIL, E
在下丘脑病变导致垂体释放促性腺激素停止的恒河猴中，持续输注外源性促性腺激素释放激素（GnRH）未能恢复持续的促性腺激素分泌。与此形成鲜明对比的是，每小时一次间歇性施用合成十肽，猴体内促性腺激素释放的生理频率重新建立了垂体促性腺激素的分泌。这种现象归因于 GnRH 的输送模式，而不是垂体细胞所暴露的这种激素的量。对有病变的动物开始连续给予 GnRH，并且通过间歇性 GnRH 替代重新建立促性腺激素分泌，可能会导致负责促性腺激素释放的过程脱敏或下调。
In rhesus monkeys with hypothalamic lesions that abolish gonadotropic hormone release by the pituitary gland, the constant infusion of exogenous gonadotropin-releasing hormone (GnRH) failed to restore sustained gonadotropin secretion. In marked contrast, intermittent administration of the synthetic decapeptide once per h, the physiological frequency of gonadotropin release in the monkey re-established pituitary gonadotropin secretion. This phenomenon was attributable to the pattern of GnRH delivery rather than to the amounts of this hormone to which the cells of the pituitary are exposed. The initiation of continuous GnRH administration in animals with lesions and in which gonadotropin secretion was re-established by intermittent GnRH replacement could result in a desensitization or down regulation of the processes responsible for gonadotropin release.