The contribution of genetic factors to phenotype and progression of drusen in early age-related macular degeneration
The contribution of genetic factors to phenotype and progression of drusen in early age-related macular degeneration
复制标题
DOI：
10.1007/s00417-014-2690-7
复制
发表时间：
2014-08-01
影响因子：
2.7
通讯作者：
Hense, Hans-Werner
中科院分区：
文献类型：
--
作者：
Dietzel, Martha;Pauleikhoff, Daniel;Hense, Hans-Werner
遗传因素有助于年龄相关性黄斑变性（AMD）的发展和进展。我们旨在评估drusen作为早期AMD的表型特征及其进展与CFH、ABCA1和ARMS2基因多态性的关系。在Munster老化和视网膜研究（MARS）中，根据国际分类，406名早期AMD患者和170名健康对照者使用眼底照片检测到dren，随访时间为2.6年（中位数）。评估了6个特征：
Genetic factors contribute to the development and progression of age-related macular degeneration (AMD). We aimed to assess the association of drusen as phenotypic characteristics of early AMD and their progression with polymorphisms in the CFH, ABCA1, and ARMS2 genes.In the Munster Aging and Retina Study (MARS), drusen were detected in 406 patients with early AMD and 170 healthy controls according to the International Classification using fundus photographs, with a follow-up examination after 2.6 years (median). Six drusen features were assessed: drusen number (