Long-term effects of sleep deprivation on neuronal activity in four hypothalamic areas
Long-term effects of sleep deprivation on neuronal activity in four hypothalamic areas
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DOI：
10.1016/j.nbd.2017.10.005
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发表时间：
2018-01-01
影响因子：
6.1
通讯作者：
Deboer, Tom
中科院分区：
文献类型：
--
作者：
Fifel, Karim;Meijer, Johanna H.;Deboer, Tom
在我们的24/7社会中，缺乏足够的睡眠变得越来越普遍。不幸的是，睡眠不足会对健康造成严重影响，包括代谢和心血管疾病以及包括抑郁症在内的精神障碍。睡眠减少对生理和行为产生不利影响的途径尚不清楚。我们发现，6小时的睡眠剥夺在成年雄性大鼠引起的神经元活动的变化，在外侧下丘脑，室旁核，弓状核和乳头体。令人惊讶的是，这些变化持续长达48小时。数据显示，睡眠不足对多个下丘脑区域的活动有长期影响。我们的数据还表明，测量脑电图慢波活动低估了下丘脑从睡眠剥夺中恢复所需的时间。我们认为，这些下丘脑的变化是睡眠不足与代谢紊乱、压力和抑郁症等多种疾病之间关系的基础，充足的睡眠对下丘脑控制的自主神经功能至关重要。
Lack of adequate sleep has become increasingly common in our 24/7 society. Unfortunately diminished sleep has significant health consequences including metabolic and cardiovascular disease and mental disorders including depression. The pathways by which reduced sleep adversely affects physiology and behavior are unknown. We found that 6 h of sleep deprivation in adult male rats induces changes in neuronal activity in the lateral hypothalamus, the paraventricular nucleus, the arcuate nucleus and the mammillary bodies. Surprisingly, these alterations last for up to 48 h. The data show that sleep loss has prolonged effects on the activity of multiple hypothalamic areas. Our data indicate also that measuring electroencephalographic slow wave activity underestimates the amount of time that the hypothalamus requires to recover from episodes of sleep deprivation. We propose that these hypothalamic changes underlie the well-established relationship between sleep loss and several diseases such as metabolic disorders, stress and depression and that sufficient sleep is vital for autonomic functions controlled by the hypothalamus.