Behavioral and psychological features in girls and women with triple-X syndrome
Behavioral and psychological features in girls and women with triple-X syndrome
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DOI：
10.1002/ajmg.a.40477
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发表时间：
2018-11-01
影响因子：
2
通讯作者：
Meyer, Jobst
中科院分区：
文献类型：
--
作者：
Freilinger, Petra;Kliegel, David;Meyer, Jobst
三重X综合征是一种常见的性染色体非整倍体，每1,000名女性中就有1人出现。我们研究的目的是描述与对照组相比，一大群患有三重X的女孩和妇女的行为特征。共纳入72例三重X受试者和69例年龄匹配的对照组受试者。心理和行为问卷被分配到三个年龄组，代表从幼儿到成年的年龄范围。至于4至7岁的女性，我们发现社会问题，注意力问题和学校表现的显着差异。对于8-17岁的年龄组，我们发现儿童行为检查表中列出的大多数量表存在较大的显著差异。最显著的差异（p < .001）来自总的行为问题，内化问题和其他四个量表。三重X的年轻女性有显着较低的一般自尊，特别是关于学校和家庭。在成年人中，有显着差异，心理症状和痛苦，在三重X主题的得分较高。无论如何，他们的平均分数仍然在正常范围内。我们没有发现任何年龄组中超过50%的三重X女性的临床证据，表明其中大约一半没有行为问题，超过60%的人在能力上与对照组没有差异。然而，我们的研究结果表明，三重X影响心理健康和个人的整体幸福感在他们的整个生命周期。
Triple-X syndrome is a common sex chromosome aneuploidy, which appears in 1 out of 1,000 females. The aim of our study was to describe the behavioral features of a large group of girls and women with triple-X in comparison to a control group. A total of 72 subjects with triple-X and 69 subjects of an age-matched control group were included. Psychological and behavioral questionnaires were allocated to three age groups, representing a range of ages from young childhood to adulthood. Regarding the females between 4 and 7 years of age, we found significant differences for social problems, attention problems, and school performance. For the age group 8-17 years, we found larger significant differences for the majority of the scales listed in the child behavior checklist. The most significant differences (p < .001) were from total behavior problems, internalizing problems, and four other scales. Young females with triple-X have significantly lower general self-esteem, especially concerning school and family. In the adults, there were significant differences concerning psychological symptoms and distress, with higher scores in the triple-X subjects. Regardless, their mean scores were still in the normal range. We did not find clinical evidence for more than 50% of the triple-X females in any age group, indicating that approximately half of them do not have behavioral problems, and that more than 60% do not differ in their competence from the control group. However, our findings suggest that triple-X influences mental health and the overall well-being of the individuals across their whole life spans.