Resveratrol, sirtuins, and the promise of a DR mimetic.
Resveratrol, sirtuins, and the promise of a DR mimetic.
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DOI：
10.1016/j.mad.2010.02.007
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发表时间：
2010-04
影响因子：
5.3
通讯作者：
Baur JA
中科院分区：
文献类型：
--
作者：
Baur JA
饮食限制（DR）可以延缓或预防与年龄相关的疾病，并延长从酵母到灵长类动物的寿命。虽然这种疗法对人类的适用性仍然不确定，但与癌症或心脏病的治愈方法相比，成比例的反应将使平均寿命增加更多的健康年数。由于许多人不太可能愿意或能够维持DR生活方式，因此人们对通过药物模仿其对健康和潜在长寿的有益影响产生了浓厚的兴趣。到目前为止，这些努力主要是由于我们缺乏对DR工作原理的机械理解而受到阻碍。Sirtuins，NAD+依赖性脱乙酰酶和ADP-核糖基转移酶，影响低等生物的寿命，已被提出是DR的关键介质，并基于此模型，Sirtuin激活剂白藜芦醇已被提出作为候选DR模拟物。事实上，白藜芦醇可以延长酵母、蠕虫、苍蝇和一种短命鱼类的寿命。在啮齿类动物中，白藜芦醇可以改善健康，防止与肥胖相关的早期死亡，但其确切的作用机制仍然是一个争论的主题，并且尚未观察到正常寿命的延长。本文综述了白藜芦醇，sirtuins，和他们的潜力，模仿DR的有益效果的最新工作。
Dietary restriction (DR) delays or prevents age-related diseases and extends lifespan in species ranging from yeast to primates. Although the applicability of this regimen to humans remains uncertain, a proportional response would add more healthy years to the average life than even a cure for cancer or heart disease. Because it is unlikely that many would be willing or able to maintain a DR lifestyle, there has been intense interest in mimicking its beneficial effects on health, and potentially longevity, with drugs. To date, such efforts have been hindered primarily by our lack of mechanistic understanding of how DR works. Sirtuins, NAD+-dependent deacetylases and ADP-ribosyltransferases that influence lifespan in lower organisms, have been proposed to be key mediators of DR, and based on this model, the sirtuin activator resveratrol has been proposed as a candidate DRmimetic. Indeed, resveratrol extends lifespan in yeast, worms, flies, and a short-lived species of fish. In rodents, resveratrol improves health, and prevents the early mortality associated with obesity, but its precise mechanism of action remains a subject of debate, and extension of normal lifespan has not been observed. This review summarizes recent work on resveratrol, sirtuins, and their potential to mimic beneficial effects of DR.
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DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
影响因子：
15.8
作者：
Civitarese AE;Carling S;Heilbronn LK;Hulver MH;Ukropcova B;Deutsch WA;Smith SR;Ravussin E;CALERIE Pennington Team
通讯作者：
CALERIE Pennington Team
DOI：
10.1073/pnas.0403493101
发表时间：
2004-08-31
影响因子：
11.1
作者：
Bauer, JH;Goupil, S;Helfand, SL
通讯作者：
Helfand, SL
影响因子：
3.9
作者：
Anisimov, VN;Berstein, LM;Franceschi, C
通讯作者：
Franceschi, C
影响因子：
10.5
作者：
Chen, Danica;Bruno, Joanne;Guarente, Leonard
通讯作者：
Guarente, Leonard