Effects of blood pressure on neuropsychological functioning in Alzheimer's disease
Effects of blood pressure on neuropsychological functioning in Alzheimer's disease
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DOI：
10.1016/s0887-6177(01)00178-0
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发表时间：
2003-01-01
影响因子：
2.6
通讯作者：
Doody, RS
中科院分区：
文献类型：
--
作者：
Davis, RN;Massman, PJ;Doody, RS
与非痴呆老年人相比，阿尔茨海默病(AD)患者的血压通常更低。阿尔茨海默病患者血压降低与脑血流量减少和皮质萎缩相关，但其对神经心理功能的影响尚不清楚。我们评估了血压对可能的AD患者(n=609)的痴呆严重程度、注意力、记忆力、语言、言语和非言语推理、运动/精神运动功能和日常生活能力(ADL)测试的影响。正如假设的那样，较低的收缩压(SBP)预示着注意力(数字向前和向后)、记忆力(视觉再现I)和ADL的减少。出乎意料的是，较低的脉压(SBP-DBP)预示着更严重的痴呆症(简易智力状态检查，MMSE)、注意力(数字向前和向后)、记忆力(逻辑记忆I和视觉再现I)和ADL。这些发现可能反映了一种趋势，即不太严重的痴呆症患者表现出与年龄相关的正常血压变化，而随着痴呆症严重程度的增加，可能会出现异常模式。(C)2002年国家神经心理学学会。爱思唯尔科学有限公司出版。版权所有。
Blood pressure is often lower among patients with Alzheimer's disease (AD) compared to nondemented older adults. Lower blood pressure in AD correlates with reduced cerebral blood flow and cortical atrophy, but its effect on neuropsychological functioning is unclear. We assessed the effects of blood pressure on tests of dementia severity, attention, memory, language., verbal and nonverbal reasoning, motor/psychomotor functioning, and activities of daily living (ADL) among probable AD patients (n = 609). As hypothesized, lower systolic blood pressure (SBP) predicted reduced attention (Digits Forward and Backward), memory (Visual Reproduction I), and ADLs. Unexpectedly, lower pulse pressure (SBP-DBP) predicted greater dementia severity (Mini-Mental State Examination, MMSE), attention (Digits Forward and Backward), memory (Logical Memory I and Visual Reproduction I), and ADLs. These findings may reflect a tendency for less severely demented patients to exhibit normal age-related changes in blood pressure, whereas abnormal patterns may develop with increased dementia severity. (C) 2002 National Academy of Neuropsychology. Published by Elsevier Science Ltd. All rights reserved.