Quantitative Evaluation Related to Disease Progression in Knee Osteoarthritis Patients During Gait
Quantitative Evaluation Related to Disease Progression in Knee Osteoarthritis Patients During Gait
复制标题
DOI：
10.14326/abe.10.51
复制
发表时间：
2021-01-01
影响因子：
1
通讯作者：
Shimada, Yoichi
中科院分区：
文献类型：
--
作者：
Tsurumiya, Kiyoshi;Hayasaka, Wataru;Shimada, Yoichi
膝骨关节炎是一种常见的下肢关节疾病。其进展会降低患者的生活质量。内翻推力（VT）是膝关节骨性关节炎患者的异常步态之一，被认为是评价膝关节骨性关节炎的有效指标。因此，几项研究使用各种测量方法评估了VT。由于VT是膝关节瞬间的侧向运动，增加了膝关节内翻角度和力矩，因此光学运动捕捉系统被广泛使用。然而，光学运动捕捉系统在临床应用中存在一些缺点，如成本高，技术要求高，附着过程耗时。最近，惯性测量单元（IMU）已经成为一种测量系统，而不是光学运动捕捉系统。基于IMU的方法被认为比光学运动捕捉系统更适合VT评估，因为它的简单性。本研究旨在使用伊穆斯评估KOA患者的步态，并根据疾病进展定量评估VT。为此，我们招募了7名健康参与者和15名KOA患者。随后，将他们的膝关节分为3个进展组：14个健康（0级）膝关节，9个3级膝关节和14个4级膝关节。作为步态测试，所有参与者都在躯干、两条大腿和两条小腿处佩戴伊穆斯，并穿过10米长的走道。VT被认为是通过伊穆斯在两个小腿处收集的内外侧加速度和内翻-外翻角速度数据的第一峰值。此后，在三个进展组之间比较和评价这些获得的数据。结果表明，KOA患者的两个峰值均显著大于健康受试者。此外，两个峰值之间存在显著的正相关。因此，这项研究有望有助于KOA的早期发现。
Knee osteoarthritis (KOA) is a common joint disease of the lower limbs. Its progression reduces the patients' quality of life. Varus thrust (VT), one of the abnormal gait patterns of KOA patients, is considered as an effective index for assessing KOA. Hence, several studies have assessed VT using various measurement methods. Since VT is the momentary lateral knee motion that increases knee varus angle and moment, optical motion capture system is widely used. However, optical motion capture system has some disadvantages in clinical usage, such as high cost, requirement of technical skills, and time-consuming attachment process. Recently, inertial measurement units (IMU) have emerged as a measurement system instead of optical motion capture systems. IMU-based method is regarded as more suitable than optical motion capture systems for VT assessment because of its simplicity. This study aimed to assess the gait of KOA patients using IMUs and to quantitatively evaluate VT based on disease progression. For this purpose, we recruited 7 healthy participants and 15 KOA patients. Subsequently, their knees were classified into 3 progression groups: 14 healthy (grade 0) knees, 9 grade 3 knees, and 14 grade 4 knees. As a gait test, all the participants wore IMUs positioned at the trunk, both thighs, and both shanks, and traversed a 10-m walkway. VT was considered as the first peak value of the mediolateral acceleration and the varus-valgus angular velocity data, which were collected via the IMUs at both shanks. Thereafter, these acquired data were compared and evaluated among the three progression groups. The results indicate that both peak values were significantly greater in the KOA patients than in the healthy subjects. Moreover, there was a significant positive correlation between the two peak values. Thus, this study is expected to contribute toward early detection of KOA.