Copper-mediated N-alkynylation of carbamates, ureas, and sulfonamides. A general method for the synthesis of ynamides
Copper-mediated N-alkynylation of carbamates, ureas, and sulfonamides. A general method for the synthesis of ynamides
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DOI：
10.1021/ol035647d
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发表时间：
2003-10-16
期刊：
影响因子：
5.2
通讯作者：
Danheiser, RL
中科院分区：
文献类型：
--
作者：
Dunetz, JR;Danheiser, RL
氨基甲酸酯、磺酰胺、手性恶唑烷酮和咪唑烷酮的n -炔基化的一般胺化策略描述。通过用KHMDS使酰胺去质子化，然后与CuI和炔基溴反应，可以得到多种取代酰胺。
A general amination strategy for the N-alkynylation of carbamates, sulfonamides, and chiral oxazolidinones and imidazolidinones is described. A variety of substituted ynamides are available by deprotonation of amides with KHMDS followed by reaction with CuI and an alkynyl bromide.