Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation.
Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation.
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DOI：
10.1155/2017/9673537
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发表时间：
2017
影响因子：
4.6
通讯作者：
Minond D
中科院分区：
文献类型：
--
作者：
Moss ML;Minond D
自发现以来，ADAM17，也被称为肿瘤坏死因子α转换酶或TACE，现在已知可以处理80多种不同的底物。其中许多底物是癌症和炎症的媒介。随着许多新的治疗ADAM17的潜在药物进入临床，ADAM金属蛋白酶领域正处于十字路口。研究人员现在已经开发出针对ADAM17的潜在药物，这些药物具有选择性，并且没有早期针对这种酶的化学实体中看到的副作用。ADAM17抑制剂具有广泛的治疗潜力，其特性包括肿瘤免疫监控和克服癌症中的药物和辐射耐药性，用于治疗心脏肥厚和炎症性肠病和类风湿性关节炎。这篇综述着重于最近发现的ADAM17底物和抑制剂，以及它们在癌症和炎症中的作用。
Since its discovery, ADAM17, also known as TNFα converting enzyme or TACE, is now known to process over 80 different substrates. Many of these substrates are mediators of cancer and inflammation. The field of ADAM metalloproteinases is at a crossroad with many of the new potential therapeutic agents for ADAM17 advancing into the clinic. Researchers have now developed potential drugs for ADAM17 that are selective and do not have the side effects which were seen in earlier chemical entities that targeted this enzyme. ADAM17 inhibitors have broad therapeutic potential, with properties ranging from tumor immunosurveillance and overcoming drug and radiation resistance in cancer, as treatments for cardiac hypertrophy and inflammatory conditions such as inflammatory bowel disease and rheumatoid arthritis. This review focuses on substrates and inhibitors identified more recently for ADAM17 and their role in cancer and inflammation.
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