Progesterone Receptor of the Human Myometrium1
Progesterone Receptor of the Human Myometrium1
复制标题
人类子宫肌层的孕酮受体1
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
G. Mikhail
中科院分区：
文献类型：
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作者：
D. Illingworth;G. P. Wood;G. Flickinger;G. Mikhail
孕酮结合蛋白的特点是在人子宫肌细胞质溶胶。受体在蔗糖梯度上沉积在4S区域，平衡解离常数为3.7 × 10 - 9 M。合成孕激素的亲和力相当于孕酮，而皮质醇的结合蛋白的亲和力较低。这些相同的孕激素显示与人CBG的结合非常低。在正常周期的妇女，总水平的细胞质受体在卵泡期高于在黄体期。服用口服避孕药的受试者和怀孕的受试者子宫肌层孕酮受体浓度最低。绝经后妇女子宫肌层受体的水平低于分泌期的周期。雌激素治疗增加绝经期子宫肌层的受体浓度的增殖期。子宫肌层胞液中雌二醇受体水平在骑自行车的妇女中也有类似的变化。当这两种结合蛋白被…
A progesterone binding protein was characterized in the cytosol of human myometrium. The receptor sedimented in the 4S region on sucrose gradients and had an equilibrium dissociation constant of 3.7 × 10−9M. Synthetic progestagens had an affinity equivalent to that of progesterone while cortisol had low affinity for the binding protein. These same progestagens showed very low binding to human CBG. In normally cycling women, the total levels of cytosol receptor were higher during the follicular phase than during the luteal phase. Subjects taking oral contraceptives and those who were pregnant had the lowest concentration of myometrial progesterone receptor. Postmenopausal women had levels of myometrial receptor lower than those of the secretory phase of the cycle. Estrogen therapy increased the receptor concentrations of the menopausal myometrium to those of the proliferative phase. The estradiol receptor levels of myometrial cytosol revealed similar changes in cycling women. When both binding proteins wer...