Stem Cells in Myometrial Physiology
Stem Cells in Myometrial Physiology
复制标题
子宫肌层生理学中的干细胞
DOI：
10.1055/s-0035-1563602
复制
发表时间：
2015
期刊：
影响因子：
2.7
通讯作者：
Maruyama T
中科院分区：
文献类型：
--
作者：
Ono M;Maruyama T
正常成人组织中含有一小部分组织特异性干细胞。这些干细胞能够自我更新并产生子代细胞，这些子代细胞注定要完全分化，从而支持组织重建和修复。人类子宫就是这样的细胞群如何支持器官功能的一个例子。子宫主要由子宫内膜和子宫肌层组成，这些组织在怀孕期间迅速扩大以支持发育中的胎儿。在女性的生殖生活中，子宫增大和重塑可能会发生十几次。妊娠子宫的扩张主要是通过子宫肌层的增殖和肥大来实现的，这些过程表明干/祖细胞系统具有重要的作用。最近，子宫肌层中的干/祖细胞已被鉴定，并对其特性进行了表征。在这里，我们讨论了子宫肌干/祖细胞的一些特性。我们还提出了一种新的子宫肌层生理学模型，以及干细胞系统如何可能有助于妊娠相关的子宫重塑。
Normal adult tissues contain a small subset of tissue-specific stem cells. These stem cells are capable of self-renewing as well as generating daughter cells that are destined to completely differentiate and thereby support tissue remodeling and repair. The human uterus is an example of how such cell populations support the function of an organ. The uterus primarily consists of endometrium and myometrium, and these tissues rapidly enlarge to support the developing fetus during pregnancy. Uterine enlargement and remodeling can occur more than a dozen times during a woman's reproductive life. The expansion of the gravid uterus is achieved mainly through myometrial hyperplasia and hypertrophy, and these processes suggest an important role for stem/progenitor cell systems. Recently, stem/progenitor cells in the myometrium have been identified and their properties characterized. Here, we discuss some of the properties of myometrial stem/progenitor cells. We also suggest a new model of myometrial physiology and how stem cell systems might contribute to pregnancy-associated uterine remodeling.