Cardiovascular research and the arrival of circadian medicine.
Cardiovascular research and the arrival of circadian medicine.
复制标题
心血管研究和昼夜节律医学的到来。
DOI：
10.1080/07420528.2022.2151862
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发表时间：
2023
影响因子：
2.8
通讯作者：
Delisle,BrianP
中科院分区：
文献类型：
--
作者：
Martino,TamiA;Delisle,BrianP
《国际时间生物学》杂志于1984年由联合主编Alain Reinberg和Michael Smolensky创办，作为时间生物学新兴科学的一个有远见的进步（Reinberg和Smolensky 1984）。第一期包括许多与人类健康相关的研究，包括心血管疾病、神经生物学、癌症、骨生长、代谢途径，以及Apple II微型计算机的余弦生物信息学程序，以及其他生物体的几篇论文。几十年来，它已成为生物和医学节律研究的领先期刊。截至2023年，《时间生物学国际》目前已有40卷，将昼夜节律生物学应用于临床医学的重要性日益显现。发表的论文涵盖了广泛的临床条件，结合了最新的最先进的技术，挑战我们更好地了解人类生理学和病理生理学，并将我们的昼夜节律研究作为疾病新疗法的基础。重要的是，我们现在知道昼夜节律与心血管生理学特别相关。例如，昼夜节律是我们每天心率、血压和自主神经系统昼夜偏差的基础。昼夜节律也是不良心血管事件（如心肌梗死、室性快速性心律失常、心源性猝死和主动脉瘤夹层或破裂）发生时间的基础（Martino and Sole 2009）。此外，昼夜节律与临床心脏病学治疗高度相关，例如高血压的时间疗法（Mistry et al. 2017）和重症监护病房的昼夜节律照明（Alibhai et al. 2014），并且可能影响经皮冠状动脉介入治疗或血管成形术或主动脉瓣置换术等外科手术后的发病率和死亡率。（Khaper et al. 2018）。最近发现了生物性别和性别对时间生物学和时间疗法的重要作用（Glen Pyle和Martino 2018），以及适合心脏修复的新型休息领域的发展（雷茨等人）。al 2022）。在2019年美国国立卫生研究院在马里兰州贝塞斯达举办了一次关于了解心脏性猝死昼夜节律机制的研讨会之后，国际时间生物学杂志上专门收集了这篇文章的想法（Delisle et al. 2021 b，2021 a）。在这次著名会议的基础上，我们联系了Mike Smolensky博士（主编1984-2021），后来又联系了RobertoRefinetti博士（主编2021）。我们的想法是将来自世界各地的科学家聚集在一起，编写一个反映当今心血管和昼夜节律研究及其在临床医学中许多令人兴奋的新应用的前沿系列。“心血管研究和昼夜节律医学的到来”是这些努力产生的令人兴奋的特别论文集，它包含来自该领域许多世界专家的原创研究，观点，荟萃分析和评论文章。“小鼠食物摄入时间揭示了心肌细胞生物钟机制在限制QT间期延长中的作用”是Schroder及其同事的原创研究文章，该文章建立在既往研究的基础上，表明心肌细胞生物钟是心脏兴奋性和心室复极的重要调节剂（Schroder等人，2022）。在这项研究中，作者发现，虽然心肌细胞生物钟对小鼠RR或QT间期的24小时节律不是强制性的，但它对限制缓慢心率下的QT间期延长很重要。“心脏肌肉功能和蛋白质的昼夜节律调节.
The journal Chronobiology International was launched in 1984 by co-Editors-in-Chief Alain Reinberg and Michael Smolensky as a visionary step forward for the emerging science of chronobiology (Reinberg and Smolensky 1984). The first issue included many studies relevant to human health including cardiovascular disease, neurobiology, cancer, bone growth, metabolic pathways, as well as cosinor bioinformatics programs for the Apple II microcomputer, and several papers on other organisms. Over the decades, it has become the leading journal of biological and medical rhythm research. As of 2023, there are now 40 volumes of Chronobiology International, and the importance of applying circadian biology to clinical medicine has become increasingly apparent. The published papers encompass a wide range of clinical conditions, incorporate the latest state-ofthe-art technologies, challenge us to better understand human physiology and pathophysiology, and apply our circadian research as a basis for new treatments for disease. Importantly, we now know that circadian rhythms are especially relevant to cardiovascular physiology. For example, circadian rhythms underlie our daily rhythmic variation in heart rate, blood pressure, and the day/night biases of our autonomic nervous system. Circadian rhythms also underlie the timing of the onset of adverse cardiovascular events such as myocardial infarction, ventricular tachyarrhythmias, sudden cardiac death, and dissection or rupture of aortic aneurysms (Martino and Sole 2009). Moreover, circadian rhythms are highly relevant to clinical cardiology therapies, such as chronotherapy for hypertension,(Mistry et al. 2017) circadian lighting in intensive care units (Alibhai et al. 2014), and can influence morbidity and mortality following surgical procedures such as percutaneous coronary intervention, or angioplasty, or aortic valve replacement.(Khaper et al. 2018). Recently the important role of biological sex and gender on chronobiology and chronotherapies (Glen Pyle and Martino 2018), and development of the novel field of rest for befitting cardiac repair have been discovered (Reitz et. al 2022). The idea for this special collection of articles in Chronobiology International was developed following an NIH workshop on Understanding the Circadian Mechanisms of Sudden Cardiac Death in Bethesda MD in 2019 (Delisle et al. 2021b, 2021a). Building on this prestigious meeting, we reached out to Dr. Mike Smolensky (Editor-in-Chief 1984–2021) and later Dr. RobertoRefinetti (Editor-in-Chief from 2021). Our idea was to bring together scientists from around the world and compile a leading edge series reflecting current day cardiovascular and circadian research and its many and varied exciting new applications to clinical medicine.“Cardiovascular Research and Arrival of Circadian Medicine” is the exciting special collection of papers that resulted from these efforts, and it contains original research, perspectives, meta-analysis, and review articles from many of the world's experts in this field.“Timing of food intake in mice unmasks a role for the cardiomyocyte circadian clock mechanism in limiting QT-interval prolongation” is an original research article by Schroder and colleagues that builds on previous studies showing that the cardiomyocyte circadian clock is an important modifier of cardiac excitability and ventricular repolarization (Schroder et al. 2022). In this study, the authors found that, while the cardiomyocyte circadian clock is not obligatory for 24-h rhythms in RR-or QT-interval in mice, it is important for limiting QT-interval prolongation at slow heart rates.“Circadian regulation of cardiac muscle function and protein …