HLA-B27:: a registry of constitutive peptide ligands
HLA-B27:: a registry of constitutive peptide ligands
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DOI：
10.1111/j.0001-2815.2004.00220.x
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发表时间：
2004-05-01
期刊：
影响因子：
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通讯作者：
Vázquez, M
中科院分区：
文献类型：
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作者：
de Castro, JAL;Alvarez, I;Vázquez, M
人类白细胞抗原 (HLA)-B27 与脊柱关节炎的密切关联可能与其肽呈递特性有关。该分子的天然多态性影响肽特异性和疾病易感性。在这项研究中，我们全面汇编了来自人类细胞内源蛋白的 HLA-B27 已知天然配体，并对多种 HLA-B27 亚型的组成肽库中的残基使用情况进行了统计评估。该分析提供的证据表明，每个肽位置，包括“非锚定”位置，都可以根据其对 HLA-B27 结合的贡献进行选择，并且还允许对已知锚定位置处的残基偏好进行量化。目前的注册表旨在作为建立可靠标准的基础，以评估 HLA-B27 多态性对肽呈递、T 细胞表位预测和分子模拟研究的影响。
The very strong association of human leukocyte antigen (HLA)-B27 with spondyloarthritis might be related to its peptide-presenting properties. The natural polymorphism of this molecule influences both peptide specificity and disease susceptibility. In this study, we present a comprehensive compilation of known natural ligands of HLA-B27 arising from endogenous proteins of human cells, together with a statistical assessment of residue usage among constitutive peptide repertoires of multiple HLA-B27 subtypes. This analysis provides evidence that every peptide position, including 'non-anchor' ones, may be subjected to selection on the basis of its contribution to HLA-B27 binding and also allows a quantization of residue preferences at known anchor positions. The present registry is intended as a basis on which to build up reliable criteria to assess the effect of HLA-B27 polymorphism on peptide presentation, for T-cell epitope predictions, and for molecular mimicry studies.