Microlithiasis and sludge
Microlithiasis and sludge
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DOI：
10.1016/j.bpg.2006.03.007
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发表时间：
2006-01-01
影响因子：
3.2
通讯作者：
Juengst, Dieter
中科院分区：
文献类型：
--
作者：
Juengst, Christoph;Kullak-Ublick, Gerd Achim;Juengst, Dieter
“污泥”是分散在液体介质中的颗粒缓慢沉降产生的固体物质。胆囊内的胆泥可以通过经腹超声检查发现，典型的回声主要来自混合胆固醇晶体的色素沉淀。一部分胆泥含有相对较大的颗粒（1-3 mm），称为微石，其形成是所有类型胆结石发展的必然中间步骤。胆汁中的微结石和淤渣可引起绞痛、胆囊炎、胆管炎和急性胰腺炎，因此具有临床意义。在这些患者中，治疗遵循有症状的胆结石疾病的指南，策略包括长期应用熊去氧胆酸，内镜乳头切开术，或最好是腹腔镜胆囊切除术。
'Sludge' is the solid material which results from the slow settling of particles dispersed in a liquid medium. Biliary sludge in the gallbladder can be detected by transabdominal ultrasonography, and the typical echoes derive mainly from pigment precipitates mixed with cholesterol crystals. A portion of biliary sludge contains comparatively large particles (1-3 mm) called microliths, the formation of which is an obligatory intermediate step in the development of all types of gallstone. Microlithiasis and sludge in bile may cause colicky pain, cholecystitis, cholangitis, and acute pancreatitis, and are thus of clinical relevance. In these patients treatment follows the guidelines of symptomatic gallstone disease, and strategies include long-term application of ursodeoxycholic acid, endoscopic papillotomy, or preferably laparoscopic cholecystectomy.