Developmental acquisition of sensory transduction in hair cells of the mouse inner ear
Developmental acquisition of sensory transduction in hair cells of the mouse inner ear
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DOI：
10.1038/nn1120
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发表时间：
2003-10-01
影响因子：
25
通讯作者：
Holt, JR
中科院分区：
文献类型：
--
作者：
Géléoc, GSG;Holt, JR
毛细胞中的感觉转导需要膜结合的转导通道、细胞外末端连接和细胞内适应马达以足够的精度组装，以赋予纳米位移敏感性。在这里，我们提出了基于FM1-43荧光、扫描电子显微镜和RT-PCR的证据，证明这三种必需元素在胚胎第16天和17天之间同时获得，也就是毛束出现后的几天(1)，并且它们的获得与机械转导的开始相吻合。
Sensory transduction in hair cells requires assembly of membrane-bound transduction channels, extracellular tip-links and intracellular adaptation motors with sufficient precision to confer nanometer displacement sensitivity. Here we present evidence based on FM1-43 fluorescence, scanning electron microscopy and RT-PCR that these three essential elements are acquired concurrently between embryonic day 16 and 17, several days after the appearance of hair bundles(1), and that their acquisition coincides with the onset of mechanotransduction.