ADAPTIVE RESPONSE AND OXIDATIVE STRESS
ADAPTIVE RESPONSE AND OXIDATIVE STRESS
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DOI：
10.2307/3432208
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发表时间：
1994-12-01
影响因子：
10.4
通讯作者：
DAVIES, KJA
中科院分区：
文献类型：
--
作者：
CRAWFORD, DR;DAVIES, KJA
细胞、组织或有机体通过先前暴露于较少的压力而更好地抵抗压力损害的能力被称为适应性反应。在所有生物体中都观察到它对许多不同的细胞毒素的反应。众所周知，氧化应激是其中的一种，它能在细菌中诱导一种适应性反应，并伴有许多蛋白质的诱导。新生蛋白的合成是对氧化应激和其他类型应激的适应性反应所必需的，这表明新合成的保护蛋白是适应所必需的。在哺乳动物细胞中也观察到对氧化应激的适应性反应。几项研究表明，为了观察哺乳动物细胞对随后高致死剂量的氧化剂的显著抵抗，有必要首先将哺乳动物细胞预先暴露于一定毒性的氧化应激中。氧化应激细胞对其他有毒物质的交叉抗性，包括γ和x射线照射、热休克、醛、重金属、MNNG、n -乙基马来酰亚胺和血红素也有报道。更详细地了解氧化适应性反应并确定所涉及的保护蛋白可能会证明具有临床益处。
The ability of a cell, tissue, or organism to better resist stress damage by prior exposure to a lesser amount of stress is known as adaptive response. It is observed in all organisms in response to a number of different cytotoxic agents. One of these agents, oxidative stress, is known to induce an adaptive response in bacteria that is accompanied by the induction of many proteins. De novo protein synthesis is required for adaptive response to oxidative and other types of stress, indicating that newly synthesized protective proteins are necessary for adaptation. Adaptive response to oxidative stress also has been observed in mammalian cells. Several studies suggest it is necessary to first preexpose mammalian cells to a somewhat toxic oxidative stress in order to observe significant resistance to a subsequent highly lethal dose of oxidant. Cross-resistance of oxidatively stressed cells to other toxic agents including gamma- and X-irradiation, heat shock, aldehydes, heavy metals, MNNG, N-ethylmaleimide, and heme also has been reported. Understanding oxidant adaptive response in more detail and identifying the protective proteins involved may prove to be of clinical benefit.