Cylindrospermopsin: cyanobacterial secondary metabolite. Biological aspects and potential risk for human health and life
Cylindrospermopsin: cyanobacterial secondary metabolite. Biological aspects and potential risk for human health and life
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DOI：
10.2478/s13545-014-0148-5
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发表时间：
2014-12-01
影响因子：
0.9
通讯作者：
Bialczyk, Jan
中科院分区：
文献类型：
--
作者：
Adamski, Michal;Chrapusta, Ewelina;Bialczyk, Jan
蓝藻球蛋白（CYN）是一种由多种蓝藻产生的细胞毒素，分布于世界各地。研究表明，CYN在动物细胞中具有广泛的生物活性，涉及肝毒性、遗传毒性、细胞毒性和致癌潜力，并被认为是导致棕榈岛（澳大利亚）和卡鲁阿鲁（巴西）人类中毒的因素之一。该化合物可能通过多种途径进入生物体，包括饮用水、鱼类和海鲜，以及在娱乐使用被蓝藻水华覆盖的水库时意外吞咽或吸入气雾剂。目前，关于氰氮对环境的影响及其在自然条件下的降解过程的研究还很少。考虑到这一点，CYN应被视为对人类健康和生命的潜在威胁。本文综述了蓝藻的理化特性、生物活性、在淡水中的存在及其对环境因子影响的敏感性。
Cylindrospermopsin (CYN) is a cytotoxin produced by several species of cyanobacteria, which occur all over the world. It was demonstrated that CYN has a wide spectrum of biological activity in animal cells, involving hepatotoxicity, genotoxicity, cytotoxicity and carcinogenic potential, and is considered as one of the factors that caused human poisoning in Palm Island (Australia) and in Caruaru (Brazil). This compound may be introduced into organism by several ways, including consumption of water, fishes and seafood as well as accidental swallowing or aerosol spray inhalation during recreational using of reservoirs covered by cyanobacterial blooms. The information about the CYN impact on environment and its degradation processes under natural conditions is scant. Taking this into consideration CYN should be regarded as a potential threat to human health and life. This review presents physicochemical characteristic and biological activity of CYN, occurrence in freshwaters and its sensitivity to the influence of some environmental factors.