Associations of genetic susceptibility to 16 cancers with risk of breast cancer overall and by intrinsic subtypes.
Associations of genetic susceptibility to 16 cancers with risk of breast cancer overall and by intrinsic subtypes.
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DOI：
10.1016/j.xhgg.2021.100077
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发表时间：
2022-01-13
期刊：
影响因子：
--
通讯作者：
Zheng W
中科院分区：
文献类型：
--
作者：
Choi J;Jia G;Wen W;Tao R;Long J;Shu XO;Zheng W
某些基因变异与患多种癌症的风险有关。我们调查了乳腺癌风险与其他16种癌症的总体遗传易感性。我们利用全基因组关联研究确定的风险变异为16种癌症构建了多基因风险评分（PRS）。我们使用乳腺癌协会联合会的数据，包括106278例病例和91477例欧洲血统的对照，评估了这些PRSs与乳腺癌风险（总体和亚型）的关系。估计比值比（OR）和95%置信区间（CIs）来衡量每种PRS与乳腺癌风险的关联。来自英国生物银行的数据，包括4337例病例和209983例非病例，被用来重复研究结果。总体乳腺癌风险显著升高5%-8%与神经胶质瘤和子宫、胃癌或结直肠癌的每单位PRS增加相关。分亚型分析显示，子宫癌（OR = 1.09, 95% CI, 1.03-1.15）和胃癌（OR = 1.07, 95% CI, 1.03-1.12）的PRS与雌激素受体阳性乳腺癌相关，卵巢癌PRS与三阴性乳腺癌相关（OR = 1.25, 95% CI, 1.01-1.55）。英国生物银行（UK Biobank）的数据支持总体乳腺癌风险与黑色素瘤、胃癌、结直肠癌和卵巢癌的PRS呈正相关。我们的研究提供了强有力的证据，证明乳腺癌与其他几种癌症具有共同的遗传易感性。我们的研究结果有助于揭示乳腺癌和其他癌症的遗传基础，并确定患有多种癌症的高风险个体。某些基因变异与多种癌症风险有关。这项研究调查了16种癌症的总体遗传易感性与乳腺癌风险之间的关系。我们的发现有助于揭示乳腺癌和其他癌症的遗传基础，并确定患有多种癌症的高风险个体。
Certain genetic variants are associated with risks of multiple cancers. We investigated breast cancer risk with overall genetic susceptibility to each of 16 other cancers. We constructed polygenic risk scores (PRS) for 16 cancers using risk variants identified by genome-wide association studies. We evaluated the associations of these PRSs with breast cancer risk (overall and by subtypes) using Breast Cancer Association Consortium data, including 106,278 cases and 91,477 controls of European ancestry. Odds ratios (OR) and 95% confidence intervals (CIs) were estimated to measure the association of each PRS with breast cancer risk. Data from the UK Biobank, including 4,337 cases and 209,983 non-cases, were used to replicate the findings. A 5%–8% significantly elevated risk of overall breast cancer was associated with per unit increase of the PRS for glioma and cancers of the corpus uteri, stomach, or colorectum. Analyses by subtype revealed that the PRS for corpus uteri cancer (OR = 1.09; 95% CI, 1.03–1.15) and stomach cancer (OR = 1.07; 95% CI, 1.03–1.12) were associated with estrogen receptor-positive breast cancer, while ovarian cancer PRS was associated with triple-negative breast cancer (OR = 1.25; 95% CI, 1.01–1.55). UK Biobank data supported the positive associations of overall breast cancer risk with PRS for melanoma and cancers of the stomach, colorectum, and ovary. Our study provides strong evidence for shared genetic susceptibility of breast cancer with several other cancers. Results from our study help uncover the genetic basis for breast and other cancers and identify individuals at high risk for multiple cancers. Certain genetic variants are associated with multiple cancer risks. This study investigated the associations of overall genetic susceptibility to each of 16 cancer types with risk of breast cancer. Our findings help uncover the genetic basis for breast and other cancers and identify individuals at high risk for multiple cancers.
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影响因子：
64.8
作者：
Michailidou K;Lindström S;Dennis J;Beesley J;Hui S;Kar S;Lemaçon A;Soucy P;Glubb D;Rostamianfar A;Bolla MK;Wang Q;Tyrer J;Dicks E;Lee A;Wang Z;Allen J;Keeman R;Eilber U;French JD;Qing Chen X;Fachal L;McCue K;McCart Reed AE;Ghoussaini M;Carroll JS;Jiang X;Finucane H;Adams M;Adank MA;Ahsan H;Aittomäki K;Anton-Culver H;Antonenkova NN;Arndt V;Aronson KJ;Arun B;Auer PL;Bacot F;Barrdahl M;Baynes C;Beckmann MW;Behrens S;Benitez J;Bermisheva M;Bernstein L;Blomqvist C;Bogdanova NV;Bojesen SE;Bonanni B;Børresen-Dale AL;Brand JS;Brauch H;Brennan P;Brenner H;Brinton L;Broberg P;Brock IW;Broeks A;Brooks-Wilson A;Brucker SY;Brüning T;Burwinkel B;Butterbach K;Cai Q;Cai H;Caldés T;Canzian F;Carracedo A;Carter BD;Castelao JE;Chan TL;David Cheng TY;Seng Chia K;Choi JY;Christiansen H;Clarke CL;NBCS Collaborators;Collée M;Conroy DM;Cordina-Duverger E;Cornelissen S;Cox DG;Cox A;Cross SS;Cunningham JM;Czene K;Daly MB;Devilee P;Doheny KF;Dörk T;Dos-Santos-Silva I;Dumont M;Durcan L;Dwek M;Eccles DM;Ekici AB;Eliassen AH;Ellberg C;Elvira M;Engel C;Eriksson M;Fasching PA;Figueroa J;Flesch-Janys D;Fletcher O;Flyger H;Fritschi L;Gaborieau V;Gabrielson M;Gago-Dominguez M;Gao YT;Gapstur SM;García-Sáenz JA;Gaudet MM;Georgoulias V;Giles GG;Glendon G;Goldberg MS;Goldgar DE;González-Neira A;Grenaker Alnæs GI;Grip M;Gronwald J;Grundy A;Guénel P;Haeberle L;Hahnen E;Haiman CA;Håkansson N;Hamann U;Hamel N;Hankinson S;Harrington P;Hart SN;Hartikainen JM;Hartman M;Hein A;Heyworth J;Hicks B;Hillemanns P;Ho DN;Hollestelle A;Hooning MJ;Hoover RN;Hopper JL;Hou MF;Hsiung CN;Huang G;Humphreys K;Ishiguro J;Ito H;Iwasaki M;Iwata H;Jakubowska A;Janni W;John EM;Johnson N;Jones K;Jones M;Jukkola-Vuorinen A;Kaaks R;Kabisch M;Kaczmarek K;Kang D;Kasuga Y;Kerin MJ;Khan S;Khusnutdinova E;Kiiski JI;Kim SW;Knight JA;Kosma VM;Kristensen VN;Krüger U;Kwong A;Lambrechts D;Le Marchand L;Lee E;Lee MH;Lee JW;Neng Lee C;Lejbkowicz F;Li J;Lilyquist J;Lindblom A;Lissowska J;Lo WY;Loibl S;Long J;Lophatananon A;Lubinski J;Luccarini C;Lux MP;Ma ESK;MacInnis RJ;Maishman T;Makalic E;Malone KE;Kostovska IM;Mannermaa A;Manoukian S;Manson JE;Margolin S;Mariapun S;Martinez ME;Matsuo K;Mavroudis D;McKay J;McLean C;Meijers-Heijboer H;Meindl A;Menéndez P;Menon U;Meyer J;Miao H;Miller N;Taib NAM;Muir K;Mulligan AM;Mulot C;Neuhausen SL;Nevanlinna H;Neven P;Nielsen SF;Noh DY;Nordestgaard BG;Norman A;Olopade OI;Olson JE;Olsson H;Olswold C;Orr N;Pankratz VS;Park SK;Park-Simon TW;Lloyd R;Perez JIA;Peterlongo P;Peto J;Phillips KA;Pinchev M;Plaseska-Karanfilska D;Prentice R;Presneau N;Prokofyeva D;Pugh E;Pylkäs K;Rack B;Radice P;Rahman N;Rennert G;Rennert HS;Rhenius V;Romero A;Romm J;Ruddy KJ;Rüdiger T;Rudolph A;Ruebner M;Rutgers EJT;Saloustros E;Sandler DP;Sangrajrang S;Sawyer EJ;Schmidt DF;Schmutzler RK;Schneeweiss A;Schoemaker MJ;Schumacher F;Schürmann P;Scott RJ;Scott C;Seal S;Seynaeve C;Shah M;Sharma P;Shen CY;Sheng G;Sherman ME;Shrubsole MJ;Shu XO;Smeets A;Sohn C;Southey MC;Spinelli JJ;Stegmaier C;Stewart-Brown S;Stone J;Stram DO;Surowy H;Swerdlow A;Tamimi R;Taylor JA;Tengström M;Teo SH;Beth Terry M;Tessier DC;Thanasitthichai S;Thöne K;Tollenaar RAEM;Tomlinson I;Tong L;Torres D;Truong T;Tseng CC;Tsugane S;Ulmer HU;Ursin G;Untch M;Vachon C;van Asperen CJ;Van Den Berg D;van den Ouweland AMW;van der Kolk L;van der Luijt RB;Vincent D;Vollenweider J;Waisfisz Q;Wang-Gohrke S;Weinberg CR;Wendt C;Whittemore AS;Wildiers H;Willett W;Winqvist R;Wolk A;Wu AH;Xia L;Yamaji T;Yang XR;Har Yip C;Yoo KY;Yu JC;Zheng W;Zheng Y;Zhu B;Ziogas A;Ziv E;ABCTB Investigators;ConFab/AOCS Investigators;Lakhani SR;Antoniou AC;Droit A;Andrulis IL;Amos CI;Couch FJ;Pharoah PDP;Chang-Claude J;Hall P;Hunter DJ;Milne RL;García-Closas M;Schmidt MK;Chanock SJ;Dunning AM;Edwards SL;Bader GD;Chenevix-Trench G;Simard J;Kraft P;Easton DF
通讯作者：
Easton DF
影响因子：
45.3
作者：
Atchley, Deann P.;Albarracin, Constance T.;Arun, Banu K.
通讯作者：
Arun, Banu K.
影响因子：
30.8
作者：
Michailidou K;Beesley J;Lindstrom S;Canisius S;Dennis J;Lush MJ;Maranian MJ;Bolla MK;Wang Q;Shah M;Perkins BJ;Czene K;Eriksson M;Darabi H;Brand JS;Bojesen SE;Nordestgaard BG;Flyger H;Nielsen SF;Rahman N;Turnbull C;BOCS;Fletcher O;Peto J;Gibson L;dos-Santos-Silva I;Chang-Claude J;Flesch-Janys D;Rudolph A;Eilber U;Behrens S;Nevanlinna H;Muranen TA;Aittomäki K;Blomqvist C;Khan S;Aaltonen K;Ahsan H;Kibriya MG;Whittemore AS;John EM;Malone KE;Gammon MD;Santella RM;Ursin G;Makalic E;Schmidt DF;Casey G;Hunter DJ;Gapstur SM;Gaudet MM;Diver WR;Haiman CA;Schumacher F;Henderson BE;Le Marchand L;Berg CD;Chanock SJ;Figueroa J;Hoover RN;Lambrechts D;Neven P;Wildiers H;van Limbergen E;Schmidt MK;Broeks A;Verhoef S;Cornelissen S;Couch FJ;Olson JE;Hallberg E;Vachon C;Waisfisz Q;Meijers-Heijboer H;Adank MA;van der Luijt RB;Li J;Liu J;Humphreys K;Kang D;Choi JY;Park SK;Yoo KY;Matsuo K;Ito H;Iwata H;Tajima K;Guénel P;Truong T;Mulot C;Sanchez M;Burwinkel B;Marme F;Surowy H;Sohn C;Wu AH;Tseng CC;Van Den Berg D;Stram DO;González-Neira A;Benitez J;Zamora MP;Perez JI;Shu XO;Lu W;Gao YT;Cai H;Cox A;Cross SS;Reed MW;Andrulis IL;Knight JA;Glendon G;Mulligan AM;Sawyer EJ;Tomlinson I;Kerin MJ;Miller N;kConFab Investigators;AOCS Group;Lindblom A;Margolin S;Teo SH;Yip CH;Taib NA;Tan GH;Hooning MJ;Hollestelle A;Martens JW;Collée JM;Blot W;Signorello LB;Cai Q;Hopper JL;Southey MC;Tsimiklis H;Apicella C;Shen CY;Hsiung CN;Wu PE;Hou MF;Kristensen VN;Nord S;Alnaes GI;NBCS;Giles GG;Milne RL;McLean C;Canzian F;Trichopoulos D;Peeters P;Lund E;Sund M;Khaw KT;Gunter MJ;Palli D;Mortensen LM;Dossus L;Huerta JM;Meindl A;Schmutzler RK;Sutter C;Yang R;Muir K;Lophatananon A;Stewart-Brown S;Siriwanarangsan P;Hartman M;Miao H;Chia KS;Chan CW;Fasching PA;Hein A;Beckmann MW;Haeberle L;Brenner H;Dieffenbach AK;Arndt V;Stegmaier C;Ashworth A;Orr N;Schoemaker MJ;Swerdlow AJ;Brinton L;Garcia-Closas M;Zheng W;Halverson SL;Shrubsole M;Long J;Goldberg MS;Labrèche F;Dumont M;Winqvist R;Pylkäs K;Jukkola-Vuorinen A;Grip M;Brauch H;Hamann U;Brüning T;GENICA Network;Radice P;Peterlongo P;Manoukian S;Bernard L;Bogdanova NV;Dörk T;Mannermaa A;Kataja V;Kosma VM;Hartikainen JM;Devilee P;Tollenaar RA;Seynaeve C;Van Asperen CJ;Jakubowska A;Lubinski J;Jaworska K;Huzarski T;Sangrajrang S;Gaborieau V;Brennan P;McKay J;Slager S;Toland AE;Ambrosone CB;Yannoukakos D;Kabisch M;Torres D;Neuhausen SL;Anton-Culver H;Luccarini C;Baynes C;Ahmed S;Healey CS;Tessier DC;Vincent D;Bacot F;Pita G;Alonso MR;Álvarez N;Herrero D;Simard J;Pharoah PP;Kraft P;Dunning AM;Chenevix-Trench G;Hall P;Easton DF
通讯作者：
Easton DF
影响因子：
16.6
作者：
Graff RE;Cavazos TB;Thai KK;Kachuri L;Rashkin SR;Hoffman JD;Alexeeff SE;Blatchins M;Meyers TJ;Leong L;Tai CG;Emami NC;Corley DA;Kushi LH;Ziv E;Van Den Eeden SK;Jorgenson E;Hoffmann TJ;Habel LA;Witte JS;Sakoda LC
通讯作者：
Sakoda LC
影响因子：
30.8
作者：
Bulik-Sullivan B;Finucane HK;Anttila V;Gusev A;Day FR;Loh PR;ReproGen Consortium;Psychiatric Genomics Consortium;Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium 3;Duncan L;Perry JR;Patterson N;Robinson EB;Daly MJ;Price AL;Neale BM
通讯作者：
Neale BM