Decontamination of ofloxacin: optimization of removal process onto sawdust using response surface methodology
Decontamination of ofloxacin: optimization of removal process onto sawdust using response surface methodology
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DOI：
10.1080/19443994.2015.1006825
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发表时间：
2016-01-02
影响因子：
1.1
通讯作者：
Ashraf, Muhammad Aqeel
中科院分区：
文献类型：
--
作者：
Qureshi, Tahira;Memon, Najma;Ashraf, Muhammad Aqeel
氧氟沙星是最常用的氟喹诺酮类药物之一，是一种有效的广谱抗生素;它也包括在被认为是环境污染物的药物活性化合物中。为了清洁水系统，吸附已被发现是去除这些污染物的有效方法。本研究展示了不同的木屑处理对去除水溶液中氧氟沙星的影响。采用响应面法和中心组合设计优化了处理木屑对氧氟沙星的吸附。使用了一组18个实验，认为pH值、吸附剂量、接触时间和山梨酸盐浓度等因素是研究去除的关键因素。与其他处理过的吸附剂相比，HCl处理过的木屑具有最大的去除效率（96%），吸附容量为47 molg（-1）。吸附剂的量对所有三种处理过的吸附剂的去除有显着的积极影响，而吸附剂的浓度对HCl处理过的锯末没有显着的积极影响。此外，吸附等温线，动力学和热力学研究到盐酸处理的木屑表明，反应是放热和自发的性质和伪二级是主要途径。氧氟沙星在木屑上的吸附是一种复杂的吸附机制，同时存在颗粒内扩散和表面吸附现象。
Ofloxacin is one of the most used fluoroquinolones, a potent broad spectrum antibiotic class; it is also included in pharmaceutically active compounds that are considered as environmental pollutants. To clean the water systems sorption has been found as an effective way to remove these pollutants. Present study demonstrates the effect of different sawdust treatments on removal of ofloxacin from aqueous solutions. The sorption of ofloxacin by treated sawdust has been optimized by response surface methodology using central composite design. Set of 18 experiments was used and factors as pH, amount of sorbent, contact time, and concentration of sorbate were considered the critical factors to be studied for removal. HCl-treated sawdust was found to have maximum removal efficiency (96%) with the sorption capacity of 47molg(-1) as compared to other treated sorbents. Amount of sorbent have significantly positive impact on the removal for all three treated sorbents whereas concentration of sorbate has non-significant positive effect for HCl-treated sawdust. Further, sorption isotherms, kinetics, and thermodynamics studies onto HCl-treated sawdust showed that reaction is exothermic and spontaneous in nature and psuedo-second-order is predominant route. Complex sorption mechanism with simultaneous intraparticle diffusion as well as surface adsorption phenomena is responsible for sorption of ofloxacin onto sawdust.