Methamphetamine and sildenafil (Viagra) use are linked to unprotected receptive and insertive anal sex, respectively, in a sample of men who have sex with men
Methamphetamine and sildenafil (Viagra) use are linked to unprotected receptive and insertive anal sex, respectively, in a sample of men who have sex with men
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DOI：
10.1136/sti.2005.017129
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发表时间：
2006-04-01
影响因子：
3.6
通讯作者：
Colfax, GN
中科院分区：
文献类型：
--
作者：
Mansergh, G;Shouse, RL;Colfax, GN
目的：有证据表明，甲基苯丙胺和西地那非（伟哥）的使用与男男性行为者 (MSM) 的性危险行为有关。我们通过进行特定的遭遇分析，调查了甲基苯丙胺、西地那非和其他物质使用与 MSM 中无保护的接受性和插入性肛交的关联。方法：数据来自对旧金山 MSM 进行的一项横断面、社区调查，调查内容涉及他们最近一次肛交时的行为。多变量回归分析了特定物质使用和人口变量与无保护肛交行为的独立关联。结果：样本 (n = 388) 在种族/民族、年龄、收入、教育、艾滋病毒状况和同性恋/双性恋身份方面具有多样性。超过一半（53%）的人报告称在最近的肛交过程中进行了无保护的肛交，包括插入性（29%）和接受性（37%）； 12% 的人报告称与 HIV 不一致或未知的伴侣进行了无保护的插入性肛交，17% 的人报告了无保护的接受性肛交。 15% 的男性在遭遇之前或期间使用了甲基苯丙胺，6% 的男性使用了西地那非； 2% 的人同时使用这两种药物。在控制人口因素和其他物质使用的多变量分析中，甲基苯丙胺的使用与无保护的性交相关（优势比（OR），2.03；95%置信区间（CI），1.09至3.76），西地那非的使用与无保护的插入性肛交（OR，6.51；CI，2.46至17.24）相关。特别是对于艾滋病毒不一致或未知的性伴侣，效果更明显。结论：甲基苯丙胺和西地那非的使用分别与无保护的接受性和插入性肛交存在特定关联，表明评估特异性和定制风险降低工作的重要性，以解决 MSM 中的某些药物和性行为角色。
Objectives: There is evidence that methamphetamine and sildenafil ( Viagra) use are associated with sexual risk behaviour among men who have sex with men (MSM). We investigated the association of methamphetamine, sildenafil, and other substance use with unprotected receptive and insertive anal sex among MSM by conducting an encounter specific analysis.Methods: Data were from a cross sectional, community based survey of MSM in San Francisco regarding behaviour during their most recent anal sex encounter. Mulitvariate regression analysed independent associations of specific substance use and demographic variables with unprotected anal sex behaviours.Results: The sample (n = 388) was diverse in race/ethnicity, age, income, education, HIV status, and homosexual/ bisexual identification. More than half (53%) reported unprotected anal sex, including insertive (29%) and receptive (37%) during their most recent anal sex encounter; 12% reported unprotected insertive and 17% reported unprotected receptive anal sex with an HIV discordant or unknown partner. Methamphetamine was used by 15% and sildenafil was used by 6% of the men before or during the encounter; 2% used both drugs. In multivariate analysis controlling for demographic factors and other substance use, methamphetamine use was associated with unprotected receptive ( odds ratio ( OR), 2.03; 95% confidence interval (CI), 1.09 to 3.76) and sildenafil use was associated with unprotected insertive ( OR, 6.51; CI, 2.46 to 17.24) anal sex. Effects were stronger with HIV discordant or unknown sex partners specifically.Conclusion: Encounter specific associations of methamphetamine and sildenafil use with unprotected receptive and insertive anal sex, respectively, indicate the importance of assessment specificity and tailoring risk reduction efforts to address certain drugs and sexual behavioural roles among MSM.