Practical considerations for the use of mTOR inhibitors.
Practical considerations for the use of mTOR inhibitors.
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DOI：
10.1186/s13737-015-0029-5
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Campistol JM
中科院分区：
文献类型：
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作者：
Diekmann F;Campistol JM
肾移植后的免疫抑制治疗是基于钙调磷酸酶抑制剂（CNI）。在大多数情况下，CNI治疗与霉酚酸酯和类固醇联合使用。尽管短期效果良好，但这种疗法与长期毒性、移植物丢失和患者死亡相关。因此，需要替代的免疫抑制策略，其将优异的疗效与低的长期不良结果发生率相结合。本文综述了基于mTOR抑制剂与最小化CNI暴露相结合的策略。
Immunosuppressive therapy after kidney transplantation is based on calcineurin inhibitors (CNI). In most cases CNI therapy is combined with mycophenolate and steroids. In spite of good short-term results this therapy is associated with long-term toxicities, graft loss and patient death. Therefore, alternative immunosuppressive strategies are needed that combine excellent efficacy with low incidences of long-term adverse outcomes. This review focuses on the strategies based on mTOR- inhibitors in combination with minimized exposure to CNI.