Establishment of intestinal bacteriology.
Establishment of intestinal bacteriology.
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DOI：
10.12938/bmfh.33.99
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发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Mitsuoka, Tomotari
中科院分区：
文献类型：
--
作者：
Mitsuoka, Tomotari
对肠道细菌的研究大约在19世纪末开始。在20世纪的最后50年里，肠道微生物区系的研究取得了长足的进步。首先，在我的工作中，我首先开发了一种肠道微生物区系的综合分析方法，然后建立了肠道厌氧菌的分类和鉴定方法。使用这些方法，我发现了一些控制肠道微生物区系的生态学规则，以及肠道微生物区系在健康和疾病中的作用。此外，使用无菌动物，已证明肠道微生物区系在宿主的癌症发生和衰老中具有作用。于是，一个新的跨学科领域--“肠道细菌学”应运而生。
Research on intestinal bacteria began around the end of the 19th century. During the last 5 decades of the 20th century, research on the intestinal microbiota made rapid progress. At first, in my work, I first developed a method of comprehensive analysis of the intestinal microbiota, and then I established classification and identification methods for intestinal anaerobes. Using these methods I discovered a number of ecological rules governing the intestinal microbiota and the role of the intestinl microbiota in health and disease. Moreover, using germfree animals, it was proven that the intestinal microbiota has a role in carcinogenesis and aging in the host. Thus, a new interdisciplinary field, "intestinal bacteriology" was established.