Cannabis in Cancer Care
Cannabis in Cancer Care
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DOI：
10.1002/cpt.108
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发表时间：
2015-06-01
影响因子：
6.7
通讯作者：
Guzman, M.
中科院分区：
文献类型：
--
作者：
Abrams, D. I.;Guzman, M.
大麻在成为目前的非法药物之前，已经在医学上使用了数千年。大麻素是大麻的活性成分，模仿内源性大麻素（内源性大麻素）的作用，激活特定的大麻素受体，特别是主要存在于中枢神经系统的CB1和主要存在于免疫功能细胞中的CB2。德尔塔-9-四氢大麻酚是这种植物中主要的生物活性大麻素，已被批准作为处方药用于治疗癌症化疗引起的恶心、呕吐和与艾滋病消耗综合征相关的厌食症。大麻素可能对癌症相关疼痛的治疗有益，可能与阿片类镇痛药协同作用。大麻素已被证明对hiv相关周围神经病变的治疗有益，这表明它们可能值得在其他神经病症状患者中进行研究。大麻素具有良好的药物安全性，但其医疗用途主要受到其精神活性作用和有限的生物利用度的限制。
Cannabis has been used in medicine for thousands of years prior to achieving its current illicit substance status. Cannabinoids, the active components of Cannabis sativa, mimic the effects of the endogenous cannabinoids (endocannabinoids), activating specific cannabinoid receptors, particularly CB1 found predominantly in the central nervous system and CB2 found predominantly in cells involved with immune function. Delta-9-tetrahydrocannabinol, the main bioactive cannabinoid in the plant, has been available as a prescription medication approved for treatment of cancer chemotherapy-induced nausea and vomiting and anorexia associated with the AIDS wasting syndrome. Cannabinoids may be of benefit in the treatment of cancer-related pain, possibly synergistic with opioid analgesics. Cannabinoids have been shown to be of benefit in the treatment of HIV-related peripheral neuropathy, suggesting that they may be worthy of study in patients with other neuropathic symptoms. Cannabinoids have a favorable drug safety profile, but their medical use is predominantly limited by their psychoactive effects and their limited bioavailability.