Copper(II) Triflate‐Catalyzed Nucleophilic Substitution of Propargylic Acetates with Enoxysilanes. A Straightforward Synthetic Route to Polysubstituted Furans
Copper(II) Triflate‐Catalyzed Nucleophilic Substitution of Propargylic Acetates with Enoxysilanes. A Straightforward Synthetic Route to Polysubstituted Furans
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DOI：
10.1002/adsc.200700234
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发表时间：
2007-09
影响因子：
5.4
通讯作者：
Zhuang-Ping Zhan;Shaopeng Wang;Xu-bin Cai;Hui-juan Liu;Jingxun Yu;Yuancun Cui
中科院分区：
文献类型：
--
作者：
Zhuang-Ping Zhan;Shaopeng Wang;Xu-bin Cai;Hui-juan Liu;Jingxun Yu;Yuancun Cui
A novel and efficient procedure for the synthesis of γ-alkynyl ketones by the nucleophilic substitution of propargylic acetates with enoxysilanes in the presence of a catalytic amount of Copper(II) triflate, has been developed. The substitution reaction can be followed by a 4-toluenesulfonic acid-catalyzed cyclization without purification of the γ-alkynyl ketone intermediates, offering a straightforward synthetic route to polysubstituted furans.
