Exercise program for nursing home residents with Alzheimer's disease:: A 1-year randomized, controlled trial
Exercise program for nursing home residents with Alzheimer's disease:: A 1-year randomized, controlled trial
复制标题
DOI：
10.1111/j.1532-5415.2007.01035.x
复制
发表时间：
2007-02-01
影响因子：
6.3
通讯作者：
Vellas, Bruno
中科院分区：
文献类型：
--
作者：
Rolland, Yves;Pillard, Fabien;Vellas, Bruno
目的：目的：探讨运动计划对改善阿尔茨海默病（AD）患者日常生活活动能力（ADL）、体能、营养状况以及减少行为障碍和抑郁的有效性。设计：随机对照试验。地点：5家疗养院。参与者：134例轻度至重度AD的门诊患者。干预：集体锻炼计划（1小时，每周两次的步行，力量，平衡和灵活性训练）或常规医疗护理12 months.MEASUREMENTS：ADL使用Katz指数进行评估。通过6米步行速度、起身行走测试和单腿平衡测试评估身体表现。采用神经精神量表、蒙哥马利和阿斯伯格抑郁评定量表以及微型营养评估行为障碍、抑郁和营养状况。对于每一个结果的措施，从基线到12个月的平均变化进行了计算，使用意向治疗analysis.RESULTS：ADL运动计划患者的平均变化从基线评分显示出比接受常规医疗护理的患者下降较慢（12个月的平均治疗差异：ADL=0.39，P= 0.02）。在12个月时观察到6米步行速度的组间显著差异，有利于锻炼计划。未观察到对行为障碍、抑郁或营养评估评分的影响。在干预组中，在探索性分析中坚持程序会话预测了执行ADL能力的变化。没有不良影响的exercised.CONCLUSION：一个简单的运动计划，1小时，每周两次，导致AD患者生活在一个养老院比常规医疗护理的ADL评分下降显着放缓。
OBJECTIVES: To investigate the effectiveness of an exercise program in improving ability to perform activities of daily living (ADLs), physical performance, and nutritional status and decreasing behavioral disturbance and depression in patients with Alzheimer's disease (AD).DESIGN: Randomized, controlled trial.SETTING: Five nursing homes.PARTICIPANTS: One hundred thirty-four ambulatory patients with mild to severe AD.INTERVENTION: Collective exercise program (1 hour, twice weekly of walk, strength, balance, and flexibility training) or routine medical care for 12 months.MEASUREMENTS: ADLs were assessed using the Katz Index of ADLs. Physical performance was evaluated using 6-meter walking speed, the get-up-and-go test, and the one-leg-balance test. Behavioral disturbance, depression, and nutritional status were evaluated using the Neuropsychiatric Inventory, the Montgomery and Asberg Depression Rating Scale, and the Mini-Nutritional Assessment. For each outcome measure, the mean change from baseline to 12 months was calculated using intention-to-treat analysis.RESULTS: ADL mean change from baseline score for exercise program patients showed a slower decline than in patients receiving routine medical care (12-month mean treatment differences: ADL=0.39, P=.02). A significant difference between the groups in favor of the exercise program was observed for 6-meter walking speed at 12 months. No effect was observed for behavioral disturbance, depression, or nutritional assessment scores. In the intervention group, adherence to the program sessions in exploratory analysis predicted change in ability to perform ADLs. No adverse effects of exercise occurred.CONCLUSION: A simple exercise program, 1 hour twice a week, led to significantly slower decline in ADL score in patients with AD living in a nursing home than routine medical care.