Sex differences in brain regional homogeneity during acute abstinence in cocaine use disorder.
Sex differences in brain regional homogeneity during acute abstinence in cocaine use disorder.
复制标题
可卡因使用障碍急性戒酒期间大脑区域均匀性的性别差异。
作者：
可卡因使用障碍（CUD）的临床特征存在显著的性别差异。由于这是一种涉及功能连接变化的大脑疾病，我们调查了CUD患者和对照组之间存在的性别差异。我们采用数据驱动的方法比较男性（n = 20, CK‐M）和女性CUD （n = 20, CK‐F）以及健康对照（20名男性，HC‐M和20名女性，HC‐F）。参与者接受静息状态功能磁共振成像检查。采用区域同质性（ReHo）来确定群体和性别差异。男女CUD患者的ReHo参数均低于对照组，尤其是顶叶内。男性CUD患者在三个右侧脑区（中央后回、壳核和梭状回）的ReHo高于女性。结果发现，戒断症状的严重程度与右侧中央后回和右侧梭状回的ReHo值降低有关。与对照组相比，CUD患者的ReHo参数发生了改变，这与衰老相关疾病的情况相似。在分析ReHo时，我们的数据还表明可卡因对大脑功能有性别特异性影响。与对照组相比，可卡因使用障碍（CUD）的参与者表现出区域同质性（ReHo）参数的改变，与衰老相关障碍的样本相似。在可卡因组中发现了特定的性别差异，男性在与感官意识、记忆和情感识别相关的大脑区域表现出更高的ReHo。我们描述了右侧中央后回和右侧梭状回在可卡因严重戒断症状中的作用。
There are significant sex differences in the clinical characteristics of cocaine use disorder (CUD). As this is a brain disorder that involves changes in functional connectivity, we investigated the existence of sex differences among people with CUD and controls. We used a data‐driven method comparing males (n = 20, CK‐M) and females with CUD (n = 20, CK‐F) and healthy controls (20 males, HC‐M and 20 females, HC‐F). The participants undertook a resting‐state functional magnetic resonance imaging exam. Regional homogeneity (ReHo) was performed to identify group and sex differences. Persons with CUD of both sexes presented lower ReHo parameters than controls, especially within the parietal lobule. Males with CUD showed higher ReHo than females in three right‐side brain areas: postcentral gyrus, putamen and fusiform gyrus. It was found that abstinence symptoms severity was associated with lower ReHo values in the right postcentral gyrus and the right fusiform gyrus. Participants with CUD exhibited altered ReHo parameters compared to controls, similar to what is found in ageing‐related disorders. Our data also indicate that cocaine has sex‐specific effects on brain functioning when analysing ReHo. Participants with cocaine use disorder (CUD) exhibited altered regional homogeneity (ReHo) parameters compared to controls, similar to those found in samples with ageing‐related disorders. Specific sex differences were identified within cocaine groups, where men show higher ReHo in brain regions related to sensory awareness, memory and emotion recognition. We described the role of the right postcentral gyrus and right fusiform gyrus in cocaine severity withdrawal symptoms.