Role of oxidative stress in stem, cancer, and cancer stem cells.
Role of oxidative stress in stem, cancer, and cancer stem cells.
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DOI：
10.3390/cancers2020859
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发表时间：
2010-05-17
期刊：
影响因子：
5.2
通讯作者：
Cho SG
中科院分区：
文献类型：
--
作者：
Dayem AA;Choi HY;Kim JH;Cho SG
术语“氧化应激”是指以活性氧（ROS）的过量产生为特征的细胞状态，并且氧化应激是干细胞、癌症和癌症干细胞的最重要的调节机制之一。癌症干细胞的概念源于对干细胞自我更新机制与癌症干细胞自我更新机制之间相似性的观察，但与正常干细胞相比，它们被认为无法控制细胞数量。ROS参与各种癌症的不同过程，并且通常已知癌细胞中ROS的增加在癌症的起始和进展中起重要作用。此外，ROS被认为是干细胞中最重要的诱变剂;当升高时，阻断自我更新，同时作为刺激干细胞分化的信号。氧化应激增强的几种信号通路被认为在癌症或癌症干细胞的肿瘤发生以及干细胞或癌症干细胞的自我更新能力中具有重要作用。线粒体在细胞凋亡中起着重要的作用，越来越多的证据支持细胞凋亡和自噬是与氧化应激密切相关的生理现象。本文综述了氧化应激对干细胞、肿瘤和肿瘤干细胞的调控作用和机制，重点介绍了氧化应激刺激的细胞信号级联反应及其在肿瘤干细胞形成中的作用机制。此外，我们解释了ROS与细胞凋亡和自噬之间的联系以及对癌症发展和治疗的影响。更好地理解这种复杂的联系可能会揭示导致更好的癌症治疗模式的机制。
The term ‘‘oxidative stress” refers to a cell’s state characterized by excessive production of reactive oxygen species (ROS) and oxidative stress is one of the most important regulatory mechanisms for stem, cancer, and cancer stem cells. The concept of cancer stem cells arose from observations of similarities between the self-renewal mechanism of stem cells and that of cancer stem cells, but compared to normal stem cells, they are believed to have no control over the cell number. ROS have been implicated in diverse processes in various cancers, and generally the increase of ROS in cancer cells is known to play an important role in the initiation and progression of cancer. Additionally, ROS have been considered as the most significant mutagens in stem cells; when elevated, blocking self-renewal and at the same time, serving as a signal stimulating stem cell differentiation. Several signaling pathways enhanced by oxidative stress are suggested to have important roles in tumorigenesis of cancer or cancer stem cells and the self-renewal ability of stem or cancer stem cells. It is now well established that mitochondria play a prominent role in apoptosis and increasing evidence supports that apoptosis and autophagy are physiological phenomena closely linked with oxidative stress. This review elucidates the effect and the mechanism of the oxidative stress on the regulation of stem, cancer, and cancer stem cells and focuses on the cell signaling cascades stimulated by oxidative stress and their mechanism in cancer stem cell formation, as very little is known about the redox status in cancer stem cells. Moreover, we explain the link between ROS and both of apoptosis and autophagy and the impact on cancer development and treatment. Better understanding of this intricate link may shed light on mechanisms that lead to better modes of cancer treatment.