Effect of age on circulating immunoreactive and bioactive parathyroid hormone levels in women.
Effect of age on circulating immunoreactive and bioactive parathyroid hormone levels in women.
复制标题
年龄对女性循环免疫反应性和生物活性甲状旁腺激素水平的影响。
DOI：
10.1002/jbmr.5650020502
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Riggs,BL
中科院分区：
文献类型：
--
作者：
Forero,MS;Klein,RF;Nissenson,RA;Nelson,K;Heath3rd,H;Arnaud,CD;Riggs,BL
尽管女性血清免疫反应性甲状旁腺激素（iPTH）水平随着年龄的增长而增加，但这可能是由于衰老的肾脏保留了非生物活性的甲状旁腺激素片段。在102名30 ~ 89岁的正常女性中，抗血清GP‐1M（具有中分子特异性）血清iPTH随年龄增加58% (r= 0.33,p< 0.001)，抗血清CH‐12M（可能具有全分子特异性）血清iPTH增加43% (r= 0.32,p< 0.001)；尿cAMP/GFR排泄量增加29% （r= 0.22,p< 0.05）。这些试验的结果通过与血清免疫提取物中生物活性甲状旁腺激素（BioPTH）的血清水平进行比较得到验证，然后在选定的25名妇女亚组中进行肾腺苷酸环化酶测定。通过抗血清GP‐1M （r= 0.48,p< 0.05）和抗血清CH‐12M （r= 0.48,p< 0.05）评估，血清BioPTH与血清iPTH相关，但与尿cAMP无关。这些数据与甲状旁腺功能随着年龄的增长而增加是一致的：显然，我们没有发现甲状旁腺功能下降，如果年龄相关的骨质流失没有部分由甲状旁腺激素介导，那么甲状旁腺功能就会下降。
Although levels of serum immunoreactive parathyroid hormone (iPTH) increase with age in women, this could be caused by retention of non‐biologically active PTH fragments by the aging kidney. In 102 normal women, aged 30 to 89 yr, serum iPTH increased with age by 58% (r= 0.33,p< 0.001) with antiserum GP‐1M (which has midmolecule specificity) and 43% (r= 0.32,p< 0.001) with antiserum CH‐12M (which may have whole molecule specificity); urinary cAMP/GFR excretion increased by 29% (r= 0.22,p< 0.05). The results of these assays were validated by comparison with serum levels of biologically active PTH (BioPTH) in immunoextracts of serum followed by renal adenylate cyclase assay in a selected subgroup of 25 of the women. Serum BioPTH correlated with serum iPTH assessed by antiserum GP‐1M (r= 0.48,p< 0.05) and antiserum CH‐12M (r= 0.48,p< 0.05) but not with urinary cAMP. The data are consistent with an increase of parathyroid function with aging: clearly, we do not find decreased parathyroid function as would be expected if age‐related bone loss was not mediated, in part, by PTH.