Current status of the development of an artificial salivary gland
Current status of the development of an artificial salivary gland
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DOI：
10.1089/ten.teb.2008.0044
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发表时间：
2008-06-01
影响因子：
6.4
通讯作者：
Palmon, Aaron
中科院分区：
文献类型：
--
作者：
Aframian, Doron J.;Palmon, Aaron
唾液腺（SG）每天分泌超过半升的唾液。唾液在维持口腔的正常内环境稳定方面具有许多功能。唾液损害有几个原因，其中头颈癌患者的放射治疗是导致患者生活质量显著下降的最令人衰弱的原因之一。在过去的十年中，其他人和我们都专注于实施组织工程原理，结合基因转移和干细胞方法来开发人工SG设备。这份手稿提供了一个概述的工程的人工SG的现状。
Salivary glands (SGs) secrete more than half a liter of saliva daily. Saliva has many functions in maintaining the normal homeostasis of the oral cavity. Several causes underlie salivary impairment, where irradiation therapy to head and neck cancer patients is one of the most debilitating causes leading to considerable decrease in the patients' quality of life. In the last decade, others and we have focused on implementing tissue engineering principles combined with gene transfer and stem cell methodologies to develop an artificial SG device. This manuscript provides an overview of the current status of engineering an artificial SG.