An efficient synthesis of highly functionalized [5,6] aromatic spiroketals by hetero-Diels-Alder reaction.
An efficient synthesis of highly functionalized [5,6] aromatic spiroketals by hetero-Diels-Alder reaction.
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DOI：
10.1021/ol7029068
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发表时间：
2008-02
期刊：
影响因子：
5.2
通讯作者：
Guanglian Zhou;Jianrong Zhu;Zhixiang Xie;Ying Li
中科院分区：
文献类型：
--
作者：
Guanglian Zhou;Jianrong Zhu;Zhixiang Xie;Ying Li
乙烯基亚砜与邻醌前体的杂diols - alder反应以中高收率和高区域选择性构建了高功能化[5,6]芳香螺旋酮骨架。这两个官能团（酮和烯烃）可以进一步进行许多合成转化。
A hetero-Diels-Alder reaction of vinyl sulfoxides with o-quinone methides precursor constructs highly functionalized [5,6] aromatic spiroketal skeletons in moderate to good yields with high regioselectivity. The two functional groups (ketone and olefin) can be further subjected to many synthetic transformations.