Hijacking Cortical Motor Output with Repetitive Microstimulation
Hijacking Cortical Motor Output with Repetitive Microstimulation
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DOI：
10.1523/jneurosci.6322-10.2011
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发表时间：
2011-09-14
影响因子：
5.3
通讯作者：
Cheney, Paul D.
中科院分区：
文献类型：
--
作者：
Griffin, Darcy M.;Hudson, Heather M.;Cheney, Paul D.
高频重复微刺激作为一种研究皮层运动输出特性的方法已被广泛应用。尽管它的广泛使用，很少有研究已经调查的活动引起的高频刺激可能与现有的活动产生的自然突触输入皮层细胞相互作用。一个合理的假设可能是，刺激诱发的活动与现有的自然活动相加。然而，另一种可能性是，刺激诱发的皮层神经元放电可能会阻止和取代自然活动。我们称后一种可能性为“神经劫持。“在两只恒河猴执行伸手抓握任务期间，对初级运动皮层的重复微刺激（200 Hz，500 ms）诱发的EMG活动进行分析的证据强烈支持神经劫持假说。
High-frequency repetitive microstimulation has been widely used as a method of investigating the properties of cortical motor output. Despite its widespread use, few studies have investigated how activity evoked by high-frequency stimulation may interact with the existing activity of cortical cells resulting from natural synaptic inputs. A reasonable assumption might be that the stimulus-evoked activity sums with the existing natural activity. However, another possibility is that the stimulus-evoked firing of cortical neurons might block and replace the natural activity. We refer to this latter possibility as "neural hijacking." Evidence from analysis of EMG activity evoked by repetitive microstimulation (200 Hz, 500 ms) of primary motor cortex in two rhesus monkeys during performance of a reach-to-grasp task strongly supports the neural hijacking hypothesis.