Effects on motor learning of transcranial alternating current stimulation applied over the primary motor cortex and cerebellar hemisphere
Effects on motor learning of transcranial alternating current stimulation applied over the primary motor cortex and cerebellar hemisphere
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DOI：
10.1016/j.jocn.2020.05.024
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发表时间：
2020-08-01
影响因子：
2
通讯作者：
Onishi, Hideaki
中科院分区：
文献类型：
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作者：
Miyaguchi, Shota;Inukai, Yasuto;Onishi, Hideaki
经颅交流电刺激（tACS）是一种非侵入性的脑刺激方法，可调节电极下皮层区域的振荡神经活动。已知在初级运动皮层（M1）和小脑半球上应用伽马（gamma）-tACS可改善运动表现;然而，尚不清楚其是否影响运动学习。因此，在这里，我们研究了在Ml和小脑半球上应用γ-tACS是否影响运动学习。该研究涉及30名健康受试者（14名女性，16名男性），在他们的右侧Ml和左侧小脑半球上施用γ-tACS或假刺激（每种条件15名受试者）期间执行视觉控制任务（8次试验）。每名受试者在24小时后进行5次试验。比较两组在不同条件下的运动学习效率、运动学习保持率和再运动学习效率。γ-tACS条件下的运动学习保持率显著高于假手术条件下的运动学习保持率（p = 0.031）。因此，给予γ-tACS的受试者在第二天的运动表现比假刺激的受试者更好。运动学习效率和再运动学习效率在不同条件下无显著差异。我们的研究结果表明，在运动学习任务期间，在Ml和小脑半球上施用γ-tACS可以增强运动学习保持。(C)2020爱思唯尔有限公司保留所有权利。
Transcranial alternating current stimulation (tACS) is a non-invasive method of brain stimulation that modulates oscillatory neural activity in the cortical area under the electrodes. Gamma (gamma)-tACS applied over the primary motor cortex (M1) and cerebellar hemisphere is known to improve motor performance; however, it is not yet known whether it affects motor learning. Thus, here we investigated whether gamma-tACS applied over the Ml and cerebellar hemisphere affects motor learning. This study involved 30 healthy subjects (14 females, 16 males) performing a visuomotor control task (eight trials) during an administration of either gamma-tACS or a sham stimulation (15 subjects per condition) over their right Ml and left cerebellar hemisphere. Each subject performed five trials after 24 h. The motor learning efficiency, motor learning retention and re-motor learning efficiency in each condition were compared. The motor learning retention in the gamma-tACS condition was significantly higher than that in the sham condition (p = 0.031). Thus, subjects who were administered gamma-tACS maintained their motor performance the next day better than sham-stimulated subjects. There was no significant difference between the conditions in the motor learning efficiency and those in the re-motor learning efficiency. Our results demonstrate that gamma-tACS administered over the Ml and cerebellar hemisphere during a motor learning task can enhance motor learning retention. (C) 2020 Elsevier Ltd. All rights reserved.