Prefrontal abnormality in children with adhd during cognitive interference control : a functional nirs study
Prefrontal abnormality in children with adhd during cognitive interference control : a functional nirs study
复制标题
DOI：
--
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Mami Nakashima;K. Matsuo;A. Hashimoto;Masayuki Nakano;Yuko Fujii;T. Matsushige;K. Egashira;Toshio Matsubara;A. Nishida;T. Ichiyama;Shinsaku Sugiyama;Yoshifumi Watanabe
中科院分区：
文献类型：
--
作者：
Mami Nakashima;K. Matsuo;A. Hashimoto;Masayuki Nakano;Yuko Fujii;T. Matsushige;K. Egashira;Toshio Matsubara;A. Nishida;T. Ichiyama;Shinsaku Sugiyama;Yoshifumi Watanabe
目的：注意力缺陷/多动障碍(ADHD)儿童表现为认知障碍，如注意力障碍和学习记忆障碍。多源干扰任务(MSIT)结合了多个维度的认知干扰，招募了扣带-额叶-顶叶认知/注意网络。本研究的目的是利用功能性近红外光谱仪(NIRS)来确定ADHD儿童在MSIT期间是否表现出额顶叶功能障碍。方法：对19例多动症患儿和14例年龄、智商相匹配的对照组进行研究。我们用46道功能性近红外成像系统测量了额顶区氧合血红蛋白浓度((oxy-Hb))的变化。比较两组在MSIT期间的行为表现和平均(oxy-Hb)。结果：MSIT的行为数据在两组间无显著差异。与对照组相比，注意缺陷多动障碍组左前额叶背外侧区的氧合血红蛋白改变(⊗10-1∓0.11；对照组为-0.6 5×10-1∓0.6 2⊗10-1；P=0.0 2)。结论：与对照组相比，ADHD儿童存在异常的额叶前额叶激活，以实现认知需求的预期结果。这些发现可能为ADHD的病理生理学提供洞察力。
Aim: Children with attention-deficit/hyperactivity disorder (ADHD) show cognitive impairments such as disrupted attention and impaired learning and memory. The multi-source interference task (MSIT) combines multiple dimensions of cognitive interference and recruits the cingulo-frontal-parietal cognitive/attention network. The aim of this study was to determine whether children with ADHD show fronto-parietal dysfunction during the MSIT by using functional near-infrared spec- troscopy (NIRS). Methods: Nineteen boys with ADHD and 14 age- and IQ-matched controls were studied. We measured oxygenated hemoglobin concentration ((oxy-Hb)) changes in the fronto-parietal region by using a 46-channel functional NIRS imaging system. The behavioral performance and mean (oxy-Hb) of the two groups during the MSIT were compared.Results: The behavioral data of the MSIT were not signifi- cantly different between the two groups. Compared to the control group, the ADHD group showed higher (oxy-Hb) changes in the left dorsolateral prefrontal region (ADHD, 0.17 ⊗ 10 -1 ∓ 0.11; control, -0.65 × 10 -1 ∓ 0.62 ⊗ 10 -1 ; P = 0.02). Conclusion: Our results suggest that compared to controls, children with ADHD have abnormal pre- frontal activation in response to multiple interference control, in order to achieve fa- vorable outcomes of cognitive demand. These findings may provide insights into the pathophysiology of ADHD.