Chronic lung inflammation in aging mice
Chronic lung inflammation in aging mice
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DOI：
10.1016/j.febslet.2007.06.075
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发表时间：
2007-07-24
期刊：
影响因子：
3.5
通讯作者：
Nagai, Atsushi
中科院分区：
文献类型：
--
作者：
Aoshiba, Kazutetsu;Nagai, Atsushi
为了确定衰老是否与肺部的促炎性转变相关，研究了12周龄和24月龄Balb/c小鼠肺部的炎症和炎症相关基因表达。cDNA微阵列和定量逆转录聚合酶链反应分析表明，8个炎症相关基因，包括CD 20，伯基特淋巴瘤受体1，CXCR-3，莫洛尼鼠白血病病毒-2的前病毒整合位点，CD 72，IL-8 RB，C-Fgr和CD 8 β，在老年小鼠上调。免疫组化结果显示，老年小鼠肺组织中CD 4、CD 8细胞、B细胞和巨噬细胞数量增多。这些结果表明，随着年龄的增长，小鼠的肺部发生了促炎性转变。(c)2007年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
To determine whether aging is associated with a pro-inflammatory shift in the lung, inflammation and inflammation-related gene expression in the lungs of 12-week-old and 24month-old Balb/c mice were studied. cDNA microarray and quantitative reverse transcription-polymerase chain reaction analyses showed that eight inflammation-related genes, including CD20, Burkitt lymphoma receptor 1, CXCR-3, provirus integration site for Moloney murine leukemia virus-2, CD72, IL-8RB, C-Fgr, and CD8 beta, were upregulated in the aged mice. Immunohistochemistry showed that the lungs of the aged mice contained increased numbers of CD4 cells, CD8 cells, B cells and macrophages. These results suggest that a pro-inflammatory shift occurs in the lungs of mice with aging. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.