Spontaneous curvature of fluid vesicles induced by trans-bilayer sugar asymmetry
Spontaneous curvature of fluid vesicles induced by trans-bilayer sugar asymmetry
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DOI：
10.1007/s002490050197
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发表时间：
1999-01-01
影响因子：
2
通讯作者：
Lipowsky, R
中科院分区：
文献类型：
--
作者：
Döbereiner, HG;Selchow, O;Lipowsky, R
我们提出测量流体脂双层的有效自发曲率作为跨双分子层不对称性的函数。实验是在微米级的囊泡上进行的，这些囊泡在不同种类的糖溶液中穿过膜。有两种效应导致这样的囊泡具有较好的曲率。这两个单层的自发曲率以及它们的面积差结合在一起，形成了有效的自发曲率。我们测量这一参数的技术允许我们使用囊泡形态作为影响弹性的一般膜-溶质相互作用的探针。
We present measurements of the effective spontaneous curvature of fluid lipid bilayers as a function of trans-bilayer asymmetry. Experiments are performed on micrometer-scale vesicles in sugar solutions with varying species across the membrane. There are two effects leading to a preferred curvature of such a vesicle. The spontaneous curvatures of the two monolayers as well as their area difference combine into an effective spontaneous curvature of the membrane. Our technique for measuring this parameter allows us to use vesicle morphology as a probe for general membrane-solute interactions affecting elasticity.