The Caudal Medial Entorhinal Cortex: a Selective Role in Recollection-Based Recognition Memory
The Caudal Medial Entorhinal Cortex: a Selective Role in Recollection-Based Recognition Memory
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DOI：
10.1523/jneurosci.4301-10.2010
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发表时间：
2010-11-17
影响因子：
5.3
通讯作者：
Eichenbaum, Howard
中科院分区：
文献类型：
--
作者：
Sauvage, Magdalena M.;Beer, Zachery;Eichenbaum, Howard
最近的研究表明尾侧内侧内嗅皮层（cMEC）专门负责路径整合和空间导航。然而，cMEC 是支持空间和非空间事件情景记忆的大脑系统的一部分，因此可能在导航以外的记忆功能中发挥作用。在这里，我们使用接受者操作特征分析来研究 cMEC 在作为大鼠非空间识别记忆基础的熟悉和回忆过程中的作用。结果表明，cMEC 在基于回忆的表现中发挥着关键和选择性的作用，支持了 cMEC 支持事件发生的空间和时间背景的记忆的观点。
Recent studies have suggested that the caudal medial entorhinal cortex (cMEC) is specialized for path integration and spatial navigation. However, cMEC is part of a brain system that supports episodic memory for both spatial and nonspatial events, and so may play a role in memory function that goes beyond navigation. Here, we used receiver operating characteristic analysis to investigate the role of the cMEC in familiarity and recollection processes that underlie nonspatial recognition memory in rats. The results indicate that cMEC plays a critical and selective role in recollection-based performance, supporting the view that cMEC supports memory for the spatial and temporal context in which events occur.