Cardiovascular drug use and the incidence of erectile dysfunction
Cardiovascular drug use and the incidence of erectile dysfunction
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DOI：
10.1038/sj.ijir.3901516
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发表时间：
2007-03-01
影响因子：
2.6
通讯作者：
Hakama, M.
中科院分区：
文献类型：
--
作者：
Shiri, R.;Koskimaki, J.;Hakama, M.
目前尚不清楚高血压本身或抗高血压药物的使用是否会导致勃起功能障碍（艾德）。本研究的目的是调查心血管疾病及其合并用药对ED发生率的影响。目标人群包括1999年居住在芬兰研究区域的55岁、65岁或75岁的男性。1999年，向2837名男性邮寄了调查问卷，5年后又向其中的2510名男性邮寄了调查问卷。随访样本包括1665名男性（66%的合格者），他们对基线和随访问卷进行了回答。研究纳入了基线时无中度或重度艾德的男性（N = 1000）。艾德通过两个关于受试者达到或维持足以进行性交的勃起能力的问题进行评估。多因素分析采用Poisson回归模型。患有高血压或心脏病的男性患艾德的风险高于未经治疗的男性。使用钙通道抑制剂的男性发生艾德的风险更高（调整后的相对风险（RR）= 1.6，95%置信区间（CI）1.0-2.4），血管紧张素II拮抗剂（RR = 2.2，95% CI 1.0-4.7）、非选择性β受体阻滞剂（RR = 1.7，95% CI 0.9-3.2）或利尿剂（RR = 1.3，CI 0.7-2.4）。艾德与使用有机硝酸盐、血管紧张素转换酶抑制剂、选择性β受体阻滞剂和血清降脂药无关。总之，钙通道抑制剂、血管紧张素II拮抗剂、非选择性β受体阻滞剂和利尿剂可能会增加ED的风险。
It is unclear whether high blood pressure per se or antihypertensive drug use causes erectile dysfunction (ED). The aim of this study was to investigate the effect of cardiovascular diseases and their concomitant medications use on the incidence of ED. The target population consisted of men aged 55, 65 or 75 years old residing in the study area in Finland in 1999. Questionnaires were mailed to 2837 men in 1999 and to 2510 of them 5 years later. The follow-up sample consisted of 1665 men (66% of those eligible) who responded to both baseline and follow-up questionnaires. Men free of moderate or severe ED at baseline (N = 1000) were included in the study. ED was assessed by two questions on subject ability to achieve or maintain an erection sufficient for intercourse. Poisson regression model was used in the multivariable analyses. The risk of ED was higher in men suffering from treated hypertension or heart disease than in those with the untreated condition. The risk of ED was higher in men using calcium channel inhibitor (adjusted relative risk (RR) = 1.6, 95% confidence interval (CI) 1.0-2.4), angiotensin II antagonist (RR = 2.2, 95% CI 1.0-4.7), non-selective beta-blocker (RR = 1.7, 95% CI 0.9-3.2) or diuretic (RR = 1.3, CI 0.7-2.4) compared with non-users. ED was not associated with using organic nitrates, angiotensin-converting enzyme inhibitors, selective beta-blockers and serum lipid-lowering agents. In summary, calcium channel inhibitors, angiotensin II antagonists, non-selective beta-blockers and diuretics may increase the risk of ED.