Identification of a potential ejaculation generator in the spinal cord
Identification of a potential ejaculation generator in the spinal cord
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DOI：
10.1126/science.1073885
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发表时间：
2002-08-30
期刊：
影响因子：
56.9
通讯作者：
Coolen, LM
中科院分区：
文献类型：
--
作者：
Truitt, WA;Coolen, LM
我们测试了大鼠腰椎脊髓丘脑细胞群对雄性性行为的意义。这些细胞的位置是将射精相关信号从生殖器官传递到大脑，它们表达神经激肽-1受体。这些神经元的选择性毒素SSP-皂草素消融导致射精行为的完全中断。相比之下，性行为的其他组成部分保持不变。这些结果表明，这群脊髓丘脑细胞在射精行为的产生中起着关键作用，可能是脊髓射精发生器的一部分。
We tested the significance of a population of lumbar spinothalamic cells for male sexual behavior in rats. These cells are positioned to relay ejaculation-related signals from reproductive organs to the brain, and they express neurokinin-1 receptors. Ablation of these neurons by the selective toxin SSP-saporin resulted in a complete disruption of ejaculatory behavior. In contrast, other components of sexual behavior remained intact. These results suggest that this population of spinothalamic cells plays a pivotal role in generation of ejaculatory behavior and may be part of a spinal ejaculation generator.