Long-term respiratory and developmental outcomes in children with bronchopulmonary dysplasia and history of tracheostomy.
Long-term respiratory and developmental outcomes in children with bronchopulmonary dysplasia and history of tracheostomy.
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DOI：
10.1038/s41372-021-01144-0
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Hayden LP
中科院分区：
文献类型：
--
作者：
Annesi CA;Levin JC;Litt JS;Sheils CA;Hayden LP
需要气管切开术（tBPD）的严重支气管肺发育不良儿童相对于未行气管切开术（sBPD）的长期发病率尚不清楚。我们比较了tBPD和sBPD的儿童肺功能和神经发育结果。在波士顿儿童医院早产肺患者登记和病历中对N = 49例tBPD和N = 280例sBPD受试者进行的回顾性病例对照研究。我们比较了NICU病程、儿童期肺功能测定和神经发育测试。tBPD受试者比sBPD受试者更有可能是黑人，患有肺动脉高压和声门下狭窄。tBPD受试者的儿童期最大FEV1%预测值（β = −0.14）和FEV 1/FVC（β = −0.08）较低;肺量测定曲线更可能提示固定性胸外梗阻。tBPD受试者有更大的认知和运动延迟<24个月，和更大的认知延迟>24个月。与不需要气管造口术的sBPD受试者相比，tBPD受试者的呼吸功能和神经发育的长期损害增加。
The long-term morbidity among children with severe bronchopulmonary dysplasia who require tracheostomy (tBPD) relative to those without tracheostomy (sBPD) is not well characterized. We compared childhood lung function and neurodevelopmental outcomes in tBPD and sBPD. Retrospective case-control study of N = 49 tBPD and N = 280 sBPD subjects in Boston Children’s Hospital Preterm Lung Patient Registry and medical record. We compared NICU course, childhood spirometry, and neurodevelopmental testing. tBPD subjects were more likely than sBPD to be Black, have pulmonary hypertension, and have subglottic stenosis. tBPD subjects had lower maximal childhood FEV1 % predicted (β = −0.14) and FEV1/FVC (β = −0.08); spirometry curves were more likely to suggest fixed extrathoracic obstruction. tBPD subjects had greater cognitive and motor delays <24 months, and greater cognitive delays >24 months. Compared to subjects with sBPD who did not require tracheostomy, tBPD subjects suffer from increased long-term impairment in respiratory function and neurodevelopment.
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发表时间：
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