Characterization of SXT/R391 Integrative and Conjugative Elements in Proteus mirabilis Isolates from Food-Producing Animals in China
Characterization of SXT/R391 Integrative and Conjugative Elements in Proteus mirabilis Isolates from Food-Producing Animals in China
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DOI：
10.1128/aac.02852-15
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发表时间：
2016-03-01
影响因子：
4.9
通讯作者：
Yang, Yong-Qiang
中科院分区：
文献类型：
--
作者：
Lei, Chang-Wei;Zhang, An-Yun;Yang, Yong-Qiang
从我国125株食用动物源奇异变形杆菌中分离到8株含有SXT/R391整合接合元件。全基因组测序显示，7个ICE与ICEPmiJpn 1相同，携带头孢菌素酶基因bla（CMY-2）。另一个被命名为ICEPmiChn 1，携带五个抗性基因。所有八个ICE可以通过接合转移到大肠杆菌。研究结果表明，养殖场是含SXT/R391 ICE奇异变形杆菌的重要储存库。
SXT/R391 integrative and conjugative elements (ICEs) were detected in 8 out of 125 Proteus mirabilis isolates from food-producing animals in China. Whole-genome sequencing revealed that seven ICEs were identical to ICEPmiJpn1, carrying the cephalosporinase gene bla(CMY-2). Another one, designated ICEPmiChn1, carried five resistance genes. All eight ICEs could be transferred to Escherichia coli via conjugation. The results highlight the idea that animal farms are important reservoir of the SXT/R391 ICE-containing P. mirabilis.