Habenula: crossroad between the basal ganglia and the limbic system.
Habenula: crossroad between the basal ganglia and the limbic system.
复制标题
DOI：
10.1523/jneurosci.3463-08.2008
复制
发表时间：
2008-11-12
期刊：
影响因子：
--
通讯作者：
Shepard PD
中科院分区：
文献类型：
--
作者：
Hikosaka O;Sesack SR;Lecourtier L;Shepard PD
越来越多的人意识到，情感、动机和奖励价值观是我们行为的重要决定因素。缰在解剖学上和功能上都具有独特的位置，参与调节某些形式的情感决策的回路。在过去的几年里，人们对这种结构，特别是外侧缰核（LHb）的兴趣激增。新的研究表明，LHb通过影响多巴胺（DA）和5-羟色胺神经元的活性，在控制运动和认知行为中起着关键作用。此外，LHb的功能障碍也与精神障碍有关，如抑郁症、精神分裂症和药物诱发的精神病。
There is a growing awareness that emotion, motivation, and reward values are important determinants of our behavior. The habenula is uniquely positioned both anatomically and functionally to participate in the circuit mediating some forms of emotive decision-making. In the last few years there has been a surge of interest in this structure, especially the lateral habenula (LHb). The new studies suggest that the LHb plays a pivotal role in controlling motor and cognitive behaviors by influencing the activity of dopamine (DA) and serotonin neurons. Further, dysfunctions of the LHb have also been implicated in psychiatric disorders, such as depression, schizophrenia, and drug-induced psychosis.