Dynamics of brown fat thermogenesis in week-old rats: evidence of relative stability during moderate cold exposure.
Dynamics of brown fat thermogenesis in week-old rats: evidence of relative stability during moderate cold exposure.
复制标题
周龄大鼠棕色脂肪生热动力学：中度寒冷暴露期间相对稳定性的证据。
DOI：
10.1086/639608
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Sokoloff,G
中科院分区：
文献类型：
--
作者：
Blumberg,MS;Sokoloff,G
包括人类在内的许多哺乳动物的新生儿主要依靠棕色脂肪组织的产热来抵御寒冷的挑战。虽然棕色脂肪组织对不同温度的稳态产热反应是众所周知的，但动态反应却很少受到关注。在这篇文章中，我们研究的相对稳定性棕色脂肪组织产热过程中短暂的扰动的空气温度。具体地说，一周大的大鼠被允许在两个水平的冷暴露之一定居。这两个水平是根据以前的工作确定的，分为中度（30.5°C）和极端（23°C）。幼崽在这些温度下安顿下来后，将它们暴露在约3.7°C的正或负空气温度扰动下。与暴露于极端空气温度的幼仔不同，经历适度空气温度扰动的幼仔表现出有组织的产热反应，使它们能够迅速返回到扰动前的状态。这些数据表明，棕色脂肪组织产热更稳定的控制比以前怀疑。
Neonates of many mammalian species, including humans, depend primarily on thermogenesis by brown adipose tissue as a defense against cold challenge. Although the steady-state thermogenic responses of brown adipose tissue to various air temperatures are well known, the dynamic responses have received relatively little attention. In this article, we examine the relative stability of brown adipose tissue thermogenesis during brief perturbations of air temperature. Specifically, week-old rats were allowed to settle at one of two levels of cold exposure. These two levels were defined on the basis of previous work as being moderate (30.5°C) or extreme (23°C). After pups had settled at these temperatures, they were exposed to positive or negative air temperature perturbations of approximately 3.7°C. Pups experiencing perturbations from the moderate air temperature, unlike those exposed to the extreme air temperature, exhibited organized thermogenic responses that allowed them to return quickly to their preperturbation conditions. These data suggest that brown adipose tissue thermogenesis is more stably controlled than has previously been suspected.