PULMONARY ARTERIAL DEVELOPMENT DURING CHILDHOOD - BRANCHING PATTERN AND STRUCTURE
PULMONARY ARTERIAL DEVELOPMENT DURING CHILDHOOD - BRANCHING PATTERN AND STRUCTURE
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DOI：
10.1136/thx.28.2.129
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发表时间：
1973-01-01
期刊：
影响因子：
10
通讯作者：
REID, L
中科院分区：
文献类型：
--
作者：
HISLOP, A;REID, L
在肺从18名儿童之间的出生和11岁的肺动脉的分支模式和结构的发展，特别是小叶内和腺泡内，已被定量分析后，注射不透射线介质。到18个月时，新的肺泡管出现，传统的动脉分支在腺泡内发育;到8岁时，随着新的肺泡形成，额外动脉的数量增加。这两种类型的血管都随年龄增长而增大，出生后直径小于200 μm的血管壁厚度立即下降，而较大的血管需要4个月才能下降到成人的厚度，这表明有两种类型的反应，一种是扩张，另一种是肌细胞生长速度的变化。在儿童期，腺泡内动脉中的肌细胞形成滞后于动脉大小的增加，使得在儿童期，腺泡内发现很少的肌性动脉。这些变化的功能意义进行了讨论。
In lungs from 18 children aged between birth and 11 years the development of the branching pattern and structure of the pulmonary arteries, particularly the intralobular and intra-acinar, has been quantitatively analysed after injection with a radio-opaque medium. Up to 18 months of age as new alveolar ducts appear conventional arterial branches develop within the acinus: supernumerary arteries increase in number up to 8 years as new alveoli form. Both types increase in size with age.After birth there is an immediate drop in wall thickness of the vessels below 200 μm diameter while the larger vessels take up to 4 months to fall to adult thickness, suggesting two types of response—one dilatation, the other a growth rate change of the muscle cells. During childhood muscle cell formation in the intra-acinar arteries lags behind increase in artery size so that during childhood few muscular arteries are found within the acinus. The functional significance of these changes is discussed.