Napping Reverses Increased Pain Sensitivity Due to Sleep Restriction
Napping Reverses Increased Pain Sensitivity Due to Sleep Restriction
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DOI：
10.1371/journal.pone.0117425
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发表时间：
2015-02-27
期刊：
影响因子：
3.7
通讯作者：
Perrot, Serge
中科院分区：
文献类型：
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作者：
Faraut, Brice;Leger, Damien;Perrot, Serge
研究目的探讨睡眠限制后的疼痛敏感性和午睡的恢复效果。设计采用严格对照的随机交叉研究，持续多导睡眠监测。以实验室为基础的研究。受试者11名健康男性志愿者。干预志愿者参加了两个为期三天的会议：单独的睡眠限制和睡眠限制和午睡。每个疗程包括一晚正常睡眠、一晚睡眠剥夺和一晚自由恢复睡眠。在睡眠剥夺之夜，参与者只被允许在02：00到04：00睡觉。在限制睡眠和午睡的过程中，志愿者们进行了两次30分钟的午睡，一次在早上，一次在下午。测量和结果在10：00和16：00对冈上肌、下背部和大腿三个区域进行了热、冷和压力的定量感觉测试。在睡眠限制后，定量感觉测试显示疼痛刺激阈值的差异变化，但在热阈值检测中没有发现差异：下背部热痛阈值降低，冈上区域压痛阈值增加，大腿无变化。午睡恢复了下背部对热痛刺激的反应和冈上区域对压力刺激的反应。结论睡眠限制在身体不同部位诱导不同类型的痛觉刺激，符合多层次的机制，这些变化被午睡逆转。小睡对痛觉阈值的恢复作用主要来自于对疼痛机制的影响，因为它与警觉状态无关。
Study ObjectiveTo investigate pain sensitivity after sleep restriction and the restorative effect of napping.DesignA strictly controlled randomized crossover study with continuous polysomnography monitoring was performed.SettingLaboratory-based study.Participants11 healthy male volunteers.InterventionsVolunteers attended two three-day sessions: "sleep restriction" alone and "sleep restriction and nap". Each session involved a baseline night of normal sleep, a night of sleep deprivation and a night of free recovery sleep. Participants were allowed to sleep only from 02:00 to 04:00 during the sleep deprivation night. During the "sleep restriction and nap" session, volunteers took two 30-minute naps, one in the morning and one in the afternoon.Measurements and ResultsQuantitative sensory testing was performed with heat, cold and pressure, at 10: 00 and 16: 00, on three areas: the supraspinatus, lower back and thigh. After sleep restriction, quantitative sensory testing revealed differential changes in pain stimuli thresholds, but not in thermal threshold detection: lower back heat pain threshold decreased, pressure pain threshold increased in the supraspinatus area and no change was observed for the thigh.Napping restored responses to heat pain stimuli in the lower back and to pressure stimuli in the supraspinatus area.ConclusionsSleep restriction induces different types of hypersensitivity to pain stimuli in different body areas, consistent with multilevel mechanisms, these changes being reversed by napping. The napping restorative effect on pain thresholds result principally from effects on pain mechanisms, since it was independent of vigilance status.