Speculation on Pathogenesis in Death from Respiratory Syncytial Virus Infection
Speculation on Pathogenesis in Death from Respiratory Syncytial Virus Infection
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呼吸道合胞病毒感染死亡发病机制的推测
DOI：
10.1016/b978-0-323-37677-8.50020-6
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
S. Court
中科院分区：
文献类型：
--
作者：
P. Gardner;J. Mcquillin;S. Court
应用荧光抗体技术对3例婴幼儿（2例毛细支气管炎和1例肺炎）的肺部进行了呼吸道合胞体（R.S.）病毒，以及人球蛋白的存在。在毛细支气管炎中，肺部几乎不含病毒，而在肺炎中，病毒大量且分布广泛;矛盾的是，在毛细支气管炎中，人球蛋白的分布与病毒一样稀少，但在肺炎中却不存在。研究表明，细支气管炎的基本过程是一种广泛的1型过敏反应，取决于第二次接触RS病毒抗原，而在R.S.病毒性肺炎粘膜坏死和肺泡及间质炎症是病毒直接损害肺部的结果。提出的另一种解释是，该过程可能是3型过敏反应。
The lungs of three infants, two with bronchiolitis and one with pneumonia, were examined by fluorescent antibody techniques for the distribution of respiratory syncytial (R.S.) virus, and also for the presence of human globulin. In bronchiolitis the lungs contained little virus, whereas in pneumonia virus was abundant and widespread; and, paradoxically, while in bronchiolitis human globulin had the same scanty distribution as virus it was absent in pneumonia. It is suggested that the essential process in bronchiolitis is a widespread type 1 allergic reaction dependent on a second encounter with R.S. virus antigen, whereas in R.S. virus pneumonia the mucosal necrosis and alveolar and interstitial inflammation are the result of direct virus damage to the lungs. The alternative explanation put forward is that the process may be a type 3 allergic reaction.